Serial femtosecond crystallography datasets from G protein-coupled receptors.
- White TA Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, 22607 Hamburg, Germany.
- Barty A Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, 22607 Hamburg, Germany.
- Liu W School of Molecular Sciences, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA.
- Ishchenko A Departments of Chemistry and Physics &Astronomy, The Bridge Institute, University of Southern California, Los Angeles, California 90089, USA.
- Zhang H Departments of Chemistry and Physics &Astronomy, The Bridge Institute, University of Southern California, Los Angeles, California 90089, USA.
- Gati C MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
- Zatsepin NA Department of Physics, Arizona State University, Tempe, Arizona 85287, USA.
- Basu S School of Molecular Sciences, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA.
- Oberthür D Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, 22607 Hamburg, Germany.
- Metz M Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, 22607 Hamburg, Germany.
- Beyerlein KR Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, 22607 Hamburg, Germany.
- Yoon CH Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, 22607 Hamburg, Germany.
- Yefanov OM Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, 22607 Hamburg, Germany.
- James D Paul Scherrer Institute, Villigen CH-5232, Switzerland.
- Wang D iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China.
- Messerschmidt M National Science Foundation BioXFEL Science and Technology Center, 700 Ellicott Street, Buffalo, New York 14203, USA.
- Koglin JE Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, Menlo Park, California 94025, USA.
- Boutet S Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, Menlo Park, California 94025, USA.
- Weierstall U Department of Physics, Arizona State University, Tempe, Arizona 85287, USA.
- Cherezov V Departments of Chemistry and Physics &Astronomy, The Bridge Institute, University of Southern California, Los Angeles, California 90089, USA.
- 2016-08-02
Published in:
- Scientific data. - 2016
English
We describe the deposition of four datasets consisting of X-ray diffraction images acquired using serial femtosecond crystallography experiments on microcrystals of human G protein-coupled receptors, grown and delivered in lipidic cubic phase, at the Linac Coherent Light Source. The receptors are: the human serotonin receptor 2B in complex with an agonist ergotamine, the human δ-opioid receptor in complex with a bi-functional peptide ligand DIPP-NH2, the human smoothened receptor in complex with an antagonist cyclopamine, and finally the human angiotensin II type 1 receptor in complex with the selective antagonist ZD7155. All four datasets have been deposited, with minimal processing, in an HDF5-based file format, which can be used directly for crystallographic processing with CrystFEL or other software. We have provided processing scripts and supporting files for recent versions of CrystFEL, which can be used to validate the data.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1038/sdata.2016.57
- PMID 27479354
- Persistent URL
- https://sonar.ch/global/documents/125802
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