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Second primary cancers in the Vaud and Neuchâtel Cancer Registries.
Journal article

Second primary cancers in the Vaud and Neuchâtel Cancer Registries.

  • Levi F aVaud Cancer Registry and Cancer Epidemiology Unit, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne bNeuchâtel Cancer Registry, Department of Health and Social Affairs, Neuchâtel, Switzerland cDepartment of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri' dDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
  • Randimbison L
  • Rafael BM
  • Manuela MC
  • La Vecchia C
  • 2014-11-15
Published in:
  • European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). - 2015
Aged
Breast Neoplasms
Carcinoma, Squamous Cell
Carcinoma, Transitional Cell
Colorectal Neoplasms
Female
Head and Neck Neoplasms
Humans
Lung Neoplasms
Male
Melanoma
Middle Aged
Neoplasms, Multiple Primary
Neoplasms, Second Primary
Prostatic Neoplasms
Registries
Skin Neoplasms
Squamous Cell Carcinoma of Head and Neck
Switzerland
Ureteral Neoplasms
Urinary Bladder Neoplasms
English An increasing proportion of new cancers is registered in patients who have received a previous cancer diagnosis. As data are inconsistent across studies, we provided information for populations long covered by valid cancer registration. Data were derived from the Swiss cancer Registries of Vaud and Neuchâtel (885,000 inhabitants). Patients diagnosed with a new malignancy (except skin basal and squamous cell carcinomas) during the period 2005-2010 were included. Over the period 2005-2010, 24,859 patients were registered with incident cancer. Of these, 3127 (13%) had multiple primary cancers and 578 (2.3%) were synchronous. Breast, prostate, colorectum, skin, melanomas, and squamous cell carcinomas of the head and neck (SHN) and bladder/ureter were the most common sites of first neoplasms, whereas breast, lung, colorectum, prostate, melanoma, and SHN were the most common sites of second neoplasms. The most common pairing was breast with breast (31% synchronous), followed by the bladder/ureter with the prostate (72% synchronous), prostate with the colorectum, SHN with SHN, and SHN with lung. Five-year crude survival of patients with synchronous cancers (34%) was not significantly lower than that of patients with single neoplasms (39%). This population-based study indicates that about one in eight incident neoplasms in these mature registries are second neoplasms and almost 1/40 patients are diagnosed with synchronous primary cancers. These are related to shared genetic and environmental factors as well as diagnostic and therapeutic procedures. As cancer diagnosis and survival is likely to improve, the proportion of patients with multiple primary cancers will further increase in the future.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/126081
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