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Presenilin-1 expression in Pick's disease.
Journal article

Presenilin-1 expression in Pick's disease.

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  • 1999-12-14
Published in:
  • Acta neuropathologica. - 1999
Aged
Female
Hippocampus
Humans
Immunohistochemistry
Male
Membrane Proteins
Neurons
Pick Disease of the Brain
Presenilin-1
English Recent studies have reported that neuronal populations expressing low levels of presenilin-1 (PS-1) display increased vulnerability in late-onset sporadic Alzheimer's disease (AD). To examine whether this phenomenon also occurs in other neurodegenerative diseases, we performed a quantitative immunocytochemical study of PS-1 distribution in the cerebral cortex of Pick's disease (PiD) cases and non-demented individuals. In PiD cases, the percentage of PS-1-containing, Pick body (PB)-free neurons was significantly elevated only in cortical areas showing neuronal loss. In these areas, PS-1 levels, measured by immunoblotting, were often higher in PiD compared to non-demented cases. Moreover, PS-1 immunoreactivity was significantly reduced in PB-containing neurons. These data suggest that as previously shown in AD, low cellular expression of PS-1 may be associated with increased neuronal loss and cellular degeneration.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/127633
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