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Targeting Antibiotic Resistance.
Journal article

Targeting Antibiotic Resistance.

  • Chellat MF Institute of Chemistry and Biotechnology, Center for Organic and Medicinal Chemistry, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland.
  • Raguž L Institute of Chemistry and Biotechnology, Center for Organic and Medicinal Chemistry, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland.
  • Riedl R Institute of Chemistry and Biotechnology, Center for Organic and Medicinal Chemistry, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland. rainer.riedl@zhaw.ch.
  • 2016-03-23
Published in:
  • Angewandte Chemie (International ed. in English). - 2016
antibiotic resistance
antibiotics
drug design
medicinal chemistry
structure-activity relationships
Anti-Bacterial Agents
Bacteria
Bacterial Proteins
Drug Design
Drug Resistance, Multiple, Bacterial
Macrolides
Molecular Dynamics Simulation
Organophosphates
Oxazoles
Oxazolidinones
Structure-Activity Relationship
English Finding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health. The past decades have seen a dramatic worldwide increase in human-pathogenic bacteria that are resistant to one or multiple antibiotics. More and more infections caused by resistant microorganisms fail to respond to conventional treatment, and in some cases, even last-resort antibiotics have lost their power. In addition, industry pipelines for the development of novel antibiotics have run dry over the past decades. A recent world health day by the World Health Organization titled "Combat drug resistance: no action today means no cure tomorrow" triggered an increase in research activity, and several promising strategies have been developed to restore treatment options against infections by resistant bacterial pathogens.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/128944
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