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The meaning of nonsense.
Journal article

The meaning of nonsense.

  • Stalder L Institute of Cell Biology, University of Berne, Baltzerstrabetae 4, 3012 Berne, Switzerland.
  • Mühlemann O
  • 2008-06-06
Published in:
  • Trends in cell biology. - 2008
Animals
Caenorhabditis elegans
Drosophila melanogaster
Evolution, Molecular
Gene Expression Regulation
Genetic Diseases, Inborn
Humans
Models, Biological
Mutation
Protein Biosynthesis
Protein Structure, Tertiary
RNA Processing, Post-Transcriptional
RNA Stability
RNA, Messenger
Saccharomyces cerevisiae
English To ensure the accuracy of gene expression, eukaryotes have evolved several surveillance mechanisms. One of the best-studied quality control mechanisms is nonsense-mediated mRNA decay (NMD), which recognizes and degrades transcripts harboring a premature translation-termination codon (PTC), thereby preventing the production of faulty proteins. NMD regulates approximately 10% of human mRNAs, and its physiological importance is manifested by the fact that approximately 30% of disease-associated mutations generate PTCs. Although different mechanisms of PTC recognition have been proposed for different species, recent studies in Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, plants and mammals suggest a conserved model. Here, we summarize the latest results and discuss an emerging model for NMD and its implications for the regulation of gene expression.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/131444
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