Aggravation of experimental cutaneous leishmaniasis in mice by administration of interleukin 3.

Feng ZY; Louis J; Kindler V; Pedrazzini T; Eliason JF; Behin R; Vassalli P

doi:10.1002/eji.1830180815

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Journal article

Aggravation of experimental cutaneous leishmaniasis in mice by administration of interleukin 3.

Feng ZY WHO-IRTC, University of Lausanne, Epalinges, Switzerland.
Louis J
Kindler V
Pedrazzini T
Eliason JF
Behin R
Vassalli P

1988-08-01

Published in:

European journal of immunology. - 1988

Antigens, Differentiation, T-Lymphocyte

Granulocyte-Macrophage Colony-Stimulating Factor

Lymphocyte Culture Test, Mixed

English Previous studies from our laboratory have shown that some in vitro maintained Leishmania major-specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin 3 (IL 3) and granulocyte-macrophage colony-stimulating factors after specific stimulation in vitro. In order to assess the involvement of such lymphokines in the exacerbation of cutaneous leishmaniasis by these L3T4+ T cells, the effect of the administration of important doses of IL 3 on the course of infection with L. major was investigated. The treatment of genetically susceptible BALB/c mice with IL 3 resulted in an enhancement of the size of lesions and favored the multiplication of parasites at anatomical sites distant from the primary lesion. Although IL 3 did not modify the development of lesions in genetically resistant CBA mice, this lymphokine promoted the growth of Leishmania in lymph node draining the lesion. Finally, the addition of IL 3 to macrophages parasitized in vitro enhanced the survival of intracellular Leishmania major.

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