Journal article
Inhibition of 5 alpha-reductase and aromatase by the ellagitannins oenothein A and oenothein B from Epilobium species.
- Ducrey B Institut de Pharmacognosie et Phytochimie, Université de Lausanne, Switzerland.
- Marston A
- Göhring S
- Hartmann RW
- Hostettmann K
- 1997-04-01
Published in:
- Planta medica. - 1997
5-alpha Reductase Inhibitors
Antineoplastic Agents, Phytogenic
Aromatase Inhibitors
Hydrolyzable Tannins
Plants, Medicinal
Tannins
English
Species of the genus Epilobium (Onagraceae) have been investigated for their activity against 5 alpha-reductase and aromatase, two enzymes which are involved in the aetiology of benign prostatic hyperplasia (BPH). Activity-guided fractionation has led to the identification of two macrocyclic ellagitannins, oenothein A (1) and oenothein B (2), as the main constituents responsible for the inhibition of the two enzymes. Quantitation of oenothein B in 10 different species of Epilobium has shown that amounts of up to 14% in the crude plant extracts are possible.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1055/s-2006-957624
- PMID 9140222
- Persistent URL
- https://sonar.ch/global/documents/137059
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