Antimicrobial susceptibility of periodontopathogenic bacteria.
- 2008-03-11
Published in:
- The Journal of antimicrobial chemotherapy. - 2008
Aggregatibacter actinomycetemcomitans
Anti-Bacterial Agents
Bacteroidaceae
Drug Resistance, Multiple, Bacterial
Microbial Sensitivity Tests
Periodontal Diseases
Time Factors
English
OBJECTIVES
The aim of this study was to evaluate the resistance profiles of Aggregatibacter (Actinobacillus) actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia/Prevotella nigrescens and to detect possible changes in antibiotic resistance over the time period of 1991-2005.
METHODS
A. actinomycetemcomitans (125 strains), P. gingivalis (152 strains) and P. intermedia/P. nigrescens (326 strains) isolated during the years 1991-2005 were tested for their susceptibility to amoxicillin/clavulanic acid, clindamycin, metronidazole, phenoxymethylpenicillin and tetracycline using the Etest.
RESULTS
No antibiotic resistance was detected in P. gingivalis, whereas a few isolates of P. intermedia were not susceptible to clindamycin (0.9%), phenoxymethylpenicillin (13.5%) or tetracycline (12.6%). Amoxicillin/clavulanic acid, tetracycline and metronidazole were the most effective antibiotics against A. actinomycetemcomitans with 0%, 0.8% and 20.8% non-susceptible isolates, respectively. However, 88% of the A. actinomycetemcomitans isolates were non-susceptible to phenoxymethylpenicillin and 88% to clindamycin. When strains isolated in the years 1991-94 were compared with those isolated in the years 2001-04, there was no statistically significant difference in the percentage of A. actinomycetemcomitans strains non-susceptible to clindamycin, metronidazole or phenoxymethylpenicillin, or in the percentage of P. intermedia strains non-susceptible to phenoxymethylpenicillin or tetracycline (P > 0.4 each).
CONCLUSIONS
Increasing antibiotic resistances in periodontopathogenic bacteria are not yet a problem in the Northern part of Switzerland.
The aim of this study was to evaluate the resistance profiles of Aggregatibacter (Actinobacillus) actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia/Prevotella nigrescens and to detect possible changes in antibiotic resistance over the time period of 1991-2005.
METHODS
A. actinomycetemcomitans (125 strains), P. gingivalis (152 strains) and P. intermedia/P. nigrescens (326 strains) isolated during the years 1991-2005 were tested for their susceptibility to amoxicillin/clavulanic acid, clindamycin, metronidazole, phenoxymethylpenicillin and tetracycline using the Etest.
RESULTS
No antibiotic resistance was detected in P. gingivalis, whereas a few isolates of P. intermedia were not susceptible to clindamycin (0.9%), phenoxymethylpenicillin (13.5%) or tetracycline (12.6%). Amoxicillin/clavulanic acid, tetracycline and metronidazole were the most effective antibiotics against A. actinomycetemcomitans with 0%, 0.8% and 20.8% non-susceptible isolates, respectively. However, 88% of the A. actinomycetemcomitans isolates were non-susceptible to phenoxymethylpenicillin and 88% to clindamycin. When strains isolated in the years 1991-94 were compared with those isolated in the years 2001-04, there was no statistically significant difference in the percentage of A. actinomycetemcomitans strains non-susceptible to clindamycin, metronidazole or phenoxymethylpenicillin, or in the percentage of P. intermedia strains non-susceptible to phenoxymethylpenicillin or tetracycline (P > 0.4 each).
CONCLUSIONS
Increasing antibiotic resistances in periodontopathogenic bacteria are not yet a problem in the Northern part of Switzerland.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1093/jac/dkn079
- PMID 18326855
- Persistent URL
- https://sonar.ch/global/documents/137625
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