Clinical assessment of fluorescence cytoscopy during transurethral bladder resection in superficial bladder cancer.
- Jichlinski P Department of Urology, University Hospital, Lausanne, Switzerland.
- Wagnières G
- Forrer M
- Mizeret J
- Guillou L
- Oswald M
- Schmidlin F
- Graber P
- Van den Bergh H
- Leisinger HJ
- 1997-01-01
Published in:
- Urological research. - 1997
Adult
Aged
Aged, 80 and over
Aminolevulinic Acid
Carcinoma, Transitional Cell
Cystoscopes
Cystoscopy
Evaluation Studies as Topic
Female
Fluorescence
Humans
Krypton
Male
Middle Aged
Photosensitizing Agents
Protoporphyrins
Sensitivity and Specificity
Urinary Bladder
Urinary Bladder Neoplasms
Urine
Xenon
English
The prognosis of superficial bladder cancer in terms of recurrence and disease progression is related to bladder tumor multiplicity and the presence of concomitant "plane" tumors such as high-grade dysplasia and carcinoma in situ. This study in 33 patients aimed to demonstrate the role of fluorescence cystoscopy in transurethral resection of superficial bladder cancer. The method is based on the detection of protoporphyrin-IX-induced fluorescence in urothelial cancer cells by topical administration of 5-aminolevulinic acid. The sensitivity and the specificity of this procedure on apparently normal mucosa in superficial bladder cancer are estimated to be 82.9% and 81.3%, respectively. Thus, fluorescence cytoscopy is a simple and reliable method for mapping the bladder mucosa, especially in the case of multifocal bladder disease, and it facilitates the screening of occult dysplasia.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1007/bf00942040
- PMID 9079749
- Persistent URL
- https://sonar.ch/global/documents/138994
Statistics
Document views: 46
File downloads:
- Full-text: 0