Motor conduction block and high titres of anti-GM1 ganglioside antibodies: pathological evidence of a motor neuropathy in a patient with lower motor neuron syndrome.
- Adams D Centre Hospitalier, Universitaire Vaudois, Lausanne, Switzerland.
- Kuntzer T
- Steck AJ
- Lobrinus A
- Janzer RC
- Regli F
- 1993-09-01
Published in:
- Journal of neurology, neurosurgery, and psychiatry. - 1993
Aged
Autoantibodies
Enzyme-Linked Immunosorbent Assay
G(M1) Ganglioside
Humans
Immunohistochemistry
Male
Motor Neuron Disease
Neural Conduction
Neuromuscular Junction
Peripheral Nerves
Spinal Cord
English
A patient with a progressive lower motor neuron syndrome and neurophysiological evidence of motor axon loss, multifocal proximal motor nerve conduction block, and high titres of anti-ganglioside GM1 antibodies. Neuropathological findings included a predominantly proximal motor radiculoneuropathy with multifocal IgG and IgM deposits on nerve fibres associated with a loss of spinal motor neurons. These findings support an autoimmune origin of this lower motor neuron syndrome with retrograde degeneration of spinal motor neurons and severe neurogenic muscular atrophy.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1136/jnnp.56.9.982
- PMID 8410039
- Persistent URL
- https://sonar.ch/global/documents/139122
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