Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats.

Entenza JM; Loeffler JM; Grandgirard D; Fischetti VA; Moreillon P

doi:10.1128/AAC.49.11.4789-4792.2005

Back

Journal article

Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats.

Entenza JM Department of Fundamental Microbiology, Biology Building, University of Lausanne, CH-1015 Lausanne, Switzerland. Jose.Entenza@unil.ch
Loeffler JM
Grandgirard D
Fischetti VA
Moreillon P

2005-10-28

Published in:

Antimicrobial agents and chemotherapy. - 2005

English Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.

Language