Pathophysiology of functional dyspepsia.
- Thumshirn M Department of Gastroenterology, University Hospital Zurich, Switzerland. miriam.thumshirn@DIM.usz.ch
- 2002-06-22
Published in:
- Gut. - 2002
Adaptation, Physiological
Dyspepsia
Gastrointestinal Motility
Helicobacter Infections
Helicobacter pylori
Humans
Nociceptors
Sensation
Visceral Afferents
English
Functional dyspepsia is a symptom complex characterised by postprandial upper abdominal discomfort or pain, early satiety, nausea, vomiting, abdominal distension, bloating, and anorexia in the absence of organic disease. Gastrointestinal motor abnormalities, altered visceral sensation, and psychosocial factors have all been identified as major pathophysiological mechanisms. This perspective has now replaced the earlier view that the condition was the result of a sole motor or sensory disorder of the stomach. Future therapeutic strategies should be aimed at reducing nociception as well as enhancing the accommodation response.
- Language
-
- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1136/gut.51.suppl_1.i63
- PMID 12077069
- Persistent URL
- https://sonar.ch/global/documents/13980
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