Decelerating decay of latently infected cells during prolonged therapy for human immunodeficiency virus type 1 infection.
- Müller V Ecology and Evolution, ETH Zürich, 8092 Zürich, Switzerland. mueller@eco.umnw.ethz.ch
- Vigueras-Gómez JF
- Bonhoeffer S
- 2002-08-07
Published in:
- Journal of virology. - 2002
Antiretroviral Therapy, Highly Active
CD4-Positive T-Lymphocytes
HIV Infections
HIV-1
Humans
Models, Biological
Time Factors
Virus Activation
Virus Latency
Virus Replication
English
Antiviral therapy induces a rapid drop in human immunodeficiency virus type 1 viremia, but the decline of virus levels decelerates over time. Mathematical modeling demonstrates that the source of residual virus production might be a single compartment of latently infected cells with an extended distribution of activation rates.
- Language
-
- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1128/jvi.76.17.8963-8965.2002
- PMID 12163616
- Persistent URL
- https://sonar.ch/global/documents/139899
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