Journal article
Mandibular osteoradionecrosis in squamous cell carcinoma of the oral cavity and oropharynx: incidence and risk factors.
- Monnier Y Otolaryngology, Head and Neck Surgery Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
- Broome M
- Betz M
- Bouferrache K
- Ozsahin M
- Jaques B
- 2011-04-16
Published in:
- Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. - 2011
Aged
Aged, 80 and over
Carcinoma, Squamous Cell
Female
Humans
Incidence
Male
Mandibular Diseases
Middle Aged
Mouth Neoplasms
Oropharyngeal Neoplasms
Osteoradionecrosis
Retrospective Studies
Risk Factors
English
OBJECTIVE
Mandibular osteoradionecrosis (ORN) is a serious complication of radiotherapy (RT) in head and neck cancer patients. The aim of this study was to analyze the incidence of and risk factors for mandibular ORN in squamous cell carcinoma (SCC) of the oral cavity and oropharynx.
STUDY DESIGN
Case series with chart review.
SETTING
University tertiary care center for head and neck oncology.
SUBJECTS AND METHODS
Seventy-three patients treated for stage I to IV SCC of the oral cavity and oropharynx between 2000 and 2007, with a minimum follow-up of 2 years, were included in the study. Treatment modalities included both RT with curative intent and adjuvant RT following tumor surgery. The log-rank test and Cox model were used for univariate and multivariate analyses.
RESULTS
The incidence of mandibular ORN was 40% at 5 years. Using univariate analysis, the following risk factors were identified: oral cavity tumors (P < .01), bone invasion (P < .02), any surgery prior to RT (P < .04), and bone surgery (P < .0001). By multivariate analysis, mandibular surgery proved to be the most important risk factor and the only one reaching statistical significance (P < .0002).
CONCLUSION
Mandibular ORN is a frequent long-term complication of RT for oral cavity and oropharynx cancers. Mandibular surgery before irradiation is the only independent risk factor. These aspects must be considered when planning treatment for these tumors.
Mandibular osteoradionecrosis (ORN) is a serious complication of radiotherapy (RT) in head and neck cancer patients. The aim of this study was to analyze the incidence of and risk factors for mandibular ORN in squamous cell carcinoma (SCC) of the oral cavity and oropharynx.
STUDY DESIGN
Case series with chart review.
SETTING
University tertiary care center for head and neck oncology.
SUBJECTS AND METHODS
Seventy-three patients treated for stage I to IV SCC of the oral cavity and oropharynx between 2000 and 2007, with a minimum follow-up of 2 years, were included in the study. Treatment modalities included both RT with curative intent and adjuvant RT following tumor surgery. The log-rank test and Cox model were used for univariate and multivariate analyses.
RESULTS
The incidence of mandibular ORN was 40% at 5 years. Using univariate analysis, the following risk factors were identified: oral cavity tumors (P < .01), bone invasion (P < .02), any surgery prior to RT (P < .04), and bone surgery (P < .0001). By multivariate analysis, mandibular surgery proved to be the most important risk factor and the only one reaching statistical significance (P < .0002).
CONCLUSION
Mandibular ORN is a frequent long-term complication of RT for oral cavity and oropharynx cancers. Mandibular surgery before irradiation is the only independent risk factor. These aspects must be considered when planning treatment for these tumors.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1177/0194599810396290
- PMID 21493361
- Persistent URL
- https://sonar.ch/global/documents/145019
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