Predictors of clinical outcomes in patients with severe aortic stenosis undergoing TAVI: a multistate analysis.
- Pilgrim T Department of Cardiology, Swiss Cardiovascular Center, Bern University Hospital, Switzerland.
- Kalesan B
- Wenaweser P
- Huber C
- Stortecky S
- Buellesfeld L
- Khattab AA
- Eberle B
- Gloekler S
- Gsponer T
- Meier B
- Jüni P
- Carrel T
- Windecker S
- 2012-11-22
Published in:
- Circulation. Cardiovascular interventions. - 2012
Acute Kidney Injury
Age Factors
Aged
Aged, 80 and over
Aortic Valve Stenosis
Atrial Fibrillation
Body Mass Index
Cardiac Catheterization
Female
Heart Valve Prosthesis Implantation
Hemorrhage
Humans
Male
Multivariate Analysis
Proportional Hazards Models
Registries
Risk Factors
Severity of Illness Index
Stroke
Time Factors
Treatment Outcome
United States
English
BACKGROUND
Patients with severe aortic stenosis at increased surgical risk continue to experience compromised long-term survival despite successful transcatheter aortic valve implantation. We used time-related pathways in a multistate analysis to identify predictors of adverse long-term outcome in patients who underwent transcatheter aortic valve implantation.
METHODS AND RESULTS
In a cohort of 389 patients with a mean age of 82.4 ± 5.8 years and a STS score of 6.8 ± 5.3 undergoing transcatheter aortic valve implantation between 2007 and 2011, multistate analysis was used to estimate mortality and stroke taking into account intercurrent events including kidney injury and the composite of access site and bleeding complications (ABC). Transapical access emerged as a predictor of kidney injury (hazard ratio [HR], 2.12; 95% confidence interval [CI] 1.00-4.47) and ABC (HR, 1.78; 95% CI, 1.07-2.96), but had no impact on the risk of stroke or death. Body mass index ≤20 kg/m(2) increased the risk of stroke or death (HR, 2.64; 95% CI, 1.25-5.54). Age >80 years (HR, 3.15; 95% CI, 1.11-8.92), body mass index ≤20 kg/m(2) (HR, 4.11; 95% CI, 1.33-12.70), prior stroke (HR, 16.42; 95% CI, 3.63-74.21), and presence of atrial fibrillation at baseline (HR, 4.12; 95% CI, 1.87-9.97) increased the risk of stroke and death after an intercurrent event of ABC.
CONCLUSIONS
A body mass index ≤20 kg/m(2) was identified as a primary predictor of stroke and death after transcatheter aortic valve implantation during long-term follow-up, whereas transapical access emerged as a predictor of kidney injury and ABC. Age >80 years, body mass index ≤20 kg/m(2), prior stroke, and presence of atrial fibrillation at baseline increased the risk of stroke and death after an intercurrent event of ABC.
Patients with severe aortic stenosis at increased surgical risk continue to experience compromised long-term survival despite successful transcatheter aortic valve implantation. We used time-related pathways in a multistate analysis to identify predictors of adverse long-term outcome in patients who underwent transcatheter aortic valve implantation.
METHODS AND RESULTS
In a cohort of 389 patients with a mean age of 82.4 ± 5.8 years and a STS score of 6.8 ± 5.3 undergoing transcatheter aortic valve implantation between 2007 and 2011, multistate analysis was used to estimate mortality and stroke taking into account intercurrent events including kidney injury and the composite of access site and bleeding complications (ABC). Transapical access emerged as a predictor of kidney injury (hazard ratio [HR], 2.12; 95% confidence interval [CI] 1.00-4.47) and ABC (HR, 1.78; 95% CI, 1.07-2.96), but had no impact on the risk of stroke or death. Body mass index ≤20 kg/m(2) increased the risk of stroke or death (HR, 2.64; 95% CI, 1.25-5.54). Age >80 years (HR, 3.15; 95% CI, 1.11-8.92), body mass index ≤20 kg/m(2) (HR, 4.11; 95% CI, 1.33-12.70), prior stroke (HR, 16.42; 95% CI, 3.63-74.21), and presence of atrial fibrillation at baseline (HR, 4.12; 95% CI, 1.87-9.97) increased the risk of stroke and death after an intercurrent event of ABC.
CONCLUSIONS
A body mass index ≤20 kg/m(2) was identified as a primary predictor of stroke and death after transcatheter aortic valve implantation during long-term follow-up, whereas transapical access emerged as a predictor of kidney injury and ABC. Age >80 years, body mass index ≤20 kg/m(2), prior stroke, and presence of atrial fibrillation at baseline increased the risk of stroke and death after an intercurrent event of ABC.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1161/CIRCINTERVENTIONS.112.974899
- PMID 23169986
- Persistent URL
- https://sonar.ch/global/documents/1453
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