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Alveolar macrophages in sarcoidosis coexpress high levels of CD86 (B7.2), CD40, and CD30L.
Journal article

Alveolar macrophages in sarcoidosis coexpress high levels of CD86 (B7.2), CD40, and CD30L.

  • Nicod LP Pulmonary Division, University Hospital of Geneva, Switzerland.
  • Isler P
  • 1997-07-01
Published in:
  • American journal of respiratory cell and molecular biology. - 1997
Adult
Aged
Antigens, CD
B7-2 Antigen
Bronchoalveolar Lavage Fluid
CD30 Ligand
CD40 Antigens
Female
Flow Cytometry
Humans
Immunophenotyping
Ki-1 Antigen
Lung Neoplasms
Lymphocyte Activation
Lymphocyte Culture Test, Mixed
Macrophages, Alveolar
Male
Membrane Glycoproteins
Reference Values
Sarcoidosis
T-Lymphocytes
English Alveolar macrophages (AM) from sarcoid patients have been shown to be good antigen presenting cells (APC) unlike normal AM which are usually ineffective. We demonstrate in ten consecutive sarcoid patients that most of their AM, unlike normal AM, do coexpress high levels of CD86, CD40, and CD30L, all known to be important for T-cell activation. CD80 is also slightly more expressed on sarcoid AM than on normal AM, but is detected on only 26 +/- 6% (mean +/- SEM) of sarcoid AM. A good correlation is present between the percentage of sarcoid AM expressing CD86 and CD40 or CD86 and CD30L. However, no correlation is found between the percentage of CD80 and CD86 positive AM in these same patients. Blocking antibodies against CD86 were able to reduce by more than 80% allogeneic T-cell proliferation induced by the AM of sarcoid patients. This study provides evidence that AM can, in pathologic states such as sarcoidosis, express functional costimulatory molecules for T-cell activation such as CD86, thought to be rather specific for more professional APC such as dendritic cells.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/145433
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