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Satellite Cell Self-Renewal.
Journal article

Satellite Cell Self-Renewal.

  • Giordani L Sorbonne Universités, UPMC Univ Paris 06, INSERM UMRS974, Center for Research in Myology, Paris, France.
  • Parisi A Nestlé Institute of Health Sciences (NIHS), Campus École Polytechnique Fédérale de Lausanne, École Polytechnique Fédérale de Lausanne Innovation Park, Lausanne, Switzerland.
  • Le Grand F Sorbonne Universités, UPMC Univ Paris 06, INSERM UMRS974, Center for Research in Myology, Paris, France. Electronic address: fabienlegrand@gmail.com.
  • 2018-01-07
Published in:
  • Current topics in developmental biology. - 2018
Satellite cells
Self-renewal
Skeletal muscle regeneration
Stem cells
Animals
Cell Differentiation
Cell Proliferation
Cell Self Renewal
Humans
Muscle Development
Muscle, Skeletal
Regeneration
Satellite Cells, Skeletal Muscle
Wound Healing
English Adult skeletal muscle is endowed with regenerative potential through partially recapitulating the embryonic developmental program. Upon acute injury or in pathological conditions, quiescent muscle-resident stem cells, called satellite cells, become activated and give rise to myogenic progenitors that massively proliferate, differentiate, and fuse to form new myofibers and restore tissue functionality. In addition, a proportion of activated cells returns back to quiescence and replenish the pool of satellite cells in order to maintain the ability of skeletal muscle tissue to repair. Self-renewal is the process by which stem cells divide to make more stem cells to maintain the stem cell population throughout life. This process is controlled by cell-intrinsic transcription factors regulated by cell-extrinsic signals from the niche and the microenvironment. This chapter provides an overview about the general aspects of satellite cell biology and focuses on the cellular and molecular aspects of satellite cell self-renewal. To date, we are still far from understanding how a very small proportion of the satellite cell progeny maintain their stem cell identity when most of their siblings progress through the myogenic program to construct myofibers.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/151190
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