Journal article
Assessment of thrombogenic potential of liposomes.
- Zbinden G Institute of Toxicology, Swiss Federal Institute of Technology, ETH, Zurich, Switzerland.
- Wunderli-Allenspach H
- Grimm L
- 1989-03-01
Published in:
- Toxicology. - 1989
Animals
Blood Coagulation
Cell Adhesion
Electrochemistry
Guinea Pigs
Humans
In Vitro Techniques
Infusions, Intravenous
Liposomes
Platelet Aggregation
Platelet Count
Surface Properties
Whole Blood Coagulation Time
English
The effects of liposomes with positive, neutral and negative surface charges on platelets and the plasmatic coagulation system were investigated in several in vitro and in vivo models. Negatively charged liposomes stimulated the plasmatic contact activating system as demonstrated by significant acceleration of whole blood clotting time measured in containers with nonwettable (siliconized) surface. The same liposomes induced reversible aggregates of human platelets in vitro and circulating reversible platelet aggregates after intravenous infusion in guinea pigs. Liposomes with positive and neutral surface charges had no effect on plasmatic coagulation and platelets. The biological mechanisms and the toxicological relevance of these findings are discussed.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/0300-483x(89)90063-2
- PMID 2705196
- Persistent URL
- https://sonar.ch/global/documents/152291
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