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Urinary CXCL9 and CXCL10 levels correlate with the extent of subclinical tubulitis.

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  • 2009-05-23
Published in:
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. - 2009
Acute-Phase Proteins
Adolescent
Adult
Aged
Alpha-Globulins
Biomarkers
Chemokine CXCL10
Chemokine CXCL9
Female
Graft Rejection
Humans
Kidney Transplantation
Kidney Tubules
Lipocalin-2
Lipocalins
Male
Middle Aged
Proto-Oncogene Proteins
Pyelonephritis
Receptors, CXCR3
English Subclinical tubulitis has been associated with the later development of interstitial fibrosis and tubular atrophy (IF/TA), leading to diminished allograft survival. The aim of this study was to investigate how concentrations of urinary CXC-receptor 3 (CXCR3) chemokines (i.e. CXCL4/9/10/11) and CCL2 relate to the extent of subclinical tubulitis. Using ELISA, urinary CXCR3 chemokines, CCL2 and tubular injury markers (i.e. urinary NGAL and alpha1-microglobulin [alpha1 m]) were measured in patients with stable estimated GFR >or=40 mL/min exhibiting normal tubular histology (n = 24), subclinical borderline tubulitis (n = 18) or subclinical tubulitis Ia/Ib (n = 22), as well as in patients with clinical tubulitis Ia/Ib (n = 17) or IF/TA (n = 10). CXCL9 and CXCL10 were significantly higher in subclinical tubulitis Ia/Ib than in subclinical borderline tubulitis (p
Language
  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/15439
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