Journal article
Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission: comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus Cy as conditioning regimen--a report from the acute leukemia working party of the European group for blood and marrow transplantation.
- Nagler A Arnon Nagler and Avichai Shimoni, Chaim Sheba Medical Center, Tel Hasomer, Israel; Vanderson Rocha, Churchill Hospital, Oxford University Hospitals, Oxford, United Kingdom; Myriam Labopin and Mohamad Mohty, Hôpital Saint-Antoine, Paris University; Gerard Socie, Hôpital St Louis, Paris; Mauricette Michallet, Hôpital Edouard Herriot, Lyon; Ibrahim Yakoub-Agha, University Hospital Lille, France; Ali Unal, Erciyes Medical School, Kayseri, Turkey; Tarek Ben Othman, Centre National de Greffe de Moelle, Tunis, Tunisia; Antonio Campos, Instituto Portugues de Oncologia do Porto, Porto, Portugal; Liisa Volin, Helsinki University Central Hospital, Helsinki, Finland; Xavier Poire, Cliniques Universitaires St Luc, Brussels, Belgium; Mahmoud Aljurf, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; Tamás Masszi, St Istvan and St Laszlo Hospital, Budapest, Hungary; Henrik Sengelov, National University Hospital, Copenhagen, Denmark; Jakob Passweg, University Hospital, Basel, Switzerland; and Hendrik Veelken, Leiden University Medical Center, Leiden, the Netherlands.
- Rocha V
- Labopin M
- Unal A
- Ben Othman T
- Campos A
- Volin L
- Poire X
- Aljurf M
- Masszi T
- Socie G
- Sengelov H
- Michallet M
- Passweg J
- Veelken H
- Yakoub-Agha I
- Shimoni A
- Mohty M
- 2013-08-28
Published in:
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 2013
Adolescent
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Busulfan
Chemoradiotherapy
Cyclophosphamide
Female
Follow-Up Studies
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Injections, Intravenous
Leukemia, Myeloid, Acute
Male
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Prognosis
Remission Induction
Retrospective Studies
Survival Rate
Transplantation Conditioning
Transplantation, Homologous
Whole-Body Irradiation
Young Adult
English
PURPOSE
Cyclophosphamide (Cy) combined with total-body irradiation (TBI) or with busulfan (Bu) are currently the most common myeloablative regimens used in allogeneic stem-cell transplantation (alloSCT) in adults with acute myelogenous leukemia (AML). Intravenous (IV) Bu has more predictable bioavailability and a safer toxicity profile than the oral formulation. Comparative studies of outcomes have been performed between oral Bu/Cy and Cy/TBI, but there have been no comparative trials in the era of IV Bu.
PATIENTS AND METHODS
We performed a retrospective registry-based study comparing outcomes of patients with AML in first or second remission after alloSCT from sibling donors who underwent IV Bu/Cy (n = 795) or Cy/TBI (n = 864) conditioning.
RESULTS
Engraftment rate was 98% and 99% after IV Bu/Cy and Cy/TBI, respectively. Grade 2 to 4 acute graft-versus-host disease (GVHD) was significantly lower in the IV Bu/Cy compared with Cy/TBI group (P < .001). Similarly, chronic GVHD was significantly lower in the IV Bu/Cy compared with Cy/TBI group (P = .003). Cumulative incidence of 2-year nonrelapse mortality (NRM; ± standard deviation [SD]) was 12% ± 1% in the IV Bu/Cy group and 15% ± 2% in the Cy/TBI group (P = .14), and 2-year relapse incidence (RI; ± SD) was 26% ± 3% and 21% ± 1%, respectively (P = .012). Leukemia-free survival (LFS) rate (± SD) was 61% ± 2% after IV Bu/Cy and 64% ± 2% after Cy/TBI (P = .27). In multivariable analysis, adjusting for differences between both groups, patients who received IV Bu/Cy had lower acute and chronic GVHD, higher RI, and a trend toward lower NRM. LFS was not statistically different between the two conditioning regimens.
CONCLUSION
This retrospective study shows that final outcomes after myeloablative conditioning using IV Bu/Cy were not statistically different from those after Cy/TBI.
Cyclophosphamide (Cy) combined with total-body irradiation (TBI) or with busulfan (Bu) are currently the most common myeloablative regimens used in allogeneic stem-cell transplantation (alloSCT) in adults with acute myelogenous leukemia (AML). Intravenous (IV) Bu has more predictable bioavailability and a safer toxicity profile than the oral formulation. Comparative studies of outcomes have been performed between oral Bu/Cy and Cy/TBI, but there have been no comparative trials in the era of IV Bu.
PATIENTS AND METHODS
We performed a retrospective registry-based study comparing outcomes of patients with AML in first or second remission after alloSCT from sibling donors who underwent IV Bu/Cy (n = 795) or Cy/TBI (n = 864) conditioning.
RESULTS
Engraftment rate was 98% and 99% after IV Bu/Cy and Cy/TBI, respectively. Grade 2 to 4 acute graft-versus-host disease (GVHD) was significantly lower in the IV Bu/Cy compared with Cy/TBI group (P < .001). Similarly, chronic GVHD was significantly lower in the IV Bu/Cy compared with Cy/TBI group (P = .003). Cumulative incidence of 2-year nonrelapse mortality (NRM; ± standard deviation [SD]) was 12% ± 1% in the IV Bu/Cy group and 15% ± 2% in the Cy/TBI group (P = .14), and 2-year relapse incidence (RI; ± SD) was 26% ± 3% and 21% ± 1%, respectively (P = .012). Leukemia-free survival (LFS) rate (± SD) was 61% ± 2% after IV Bu/Cy and 64% ± 2% after Cy/TBI (P = .27). In multivariable analysis, adjusting for differences between both groups, patients who received IV Bu/Cy had lower acute and chronic GVHD, higher RI, and a trend toward lower NRM. LFS was not statistically different between the two conditioning regimens.
CONCLUSION
This retrospective study shows that final outcomes after myeloablative conditioning using IV Bu/Cy were not statistically different from those after Cy/TBI.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1200/JCO.2013.48.8114
- PMID 23980086
- Persistent URL
- https://sonar.ch/global/documents/159813
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