Journal article
PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle.
- Dinulovic I Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
- Furrer R Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
- Di Fulvio S Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
- Ferry A Thérapie des maladies du muscle strié INSERM U974 - CNRS UMR7215 - UPMC UM76, Institut de Myologie and University Rene Descartes, 47, bld de l'Hôpital, G.H. Pitié-Salpétrière, 75013 Paris, France.
- Beer M Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
- Handschin C Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
- 2016-11-12
Published in:
- Skeletal muscle. - 2016
Fibrosis
Inflammation
Macrophages
Necrosis
PGC-1α
Regeneration
Animals
Cobra Cardiotoxin Proteins
Fibrosis
Gene Expression
Hydroxyproline
Macrophages
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Muscle Contraction
Muscle, Skeletal
Myositis
Necrosis
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Regeneration
English
BACKGROUND
Skeletal muscle tissue has an enormous regenerative capacity that is instrumental for a successful defense against muscle injury and wasting. The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) exerts therapeutic effects in several muscle pathologies, but its role in damage-induced muscle regeneration is unclear.
METHODS
Using muscle-specific gain- and loss-of-function models for PGC-1α in combination with the myotoxic agent cardiotoxin (CTX), we explored the role of this transcriptional coactivator in muscle damage and inflammation.
RESULTS
Interestingly, we observed PGC-1α-dependent effects at the early stages of regeneration, in particular regarding macrophage accumulation and polarization from the pro-inflammatory M1 to the anti-inflammatory M2 type, a faster resolution of necrosis and protection against the development of fibrosis after multiple CTX-induced injuries.
CONCLUSIONS
PGC-1α exerts beneficial effects on muscle inflammation that might contribute to the therapeutic effects of elevated muscle PGC-1α in different models of muscle wasting.
Skeletal muscle tissue has an enormous regenerative capacity that is instrumental for a successful defense against muscle injury and wasting. The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) exerts therapeutic effects in several muscle pathologies, but its role in damage-induced muscle regeneration is unclear.
METHODS
Using muscle-specific gain- and loss-of-function models for PGC-1α in combination with the myotoxic agent cardiotoxin (CTX), we explored the role of this transcriptional coactivator in muscle damage and inflammation.
RESULTS
Interestingly, we observed PGC-1α-dependent effects at the early stages of regeneration, in particular regarding macrophage accumulation and polarization from the pro-inflammatory M1 to the anti-inflammatory M2 type, a faster resolution of necrosis and protection against the development of fibrosis after multiple CTX-induced injuries.
CONCLUSIONS
PGC-1α exerts beneficial effects on muscle inflammation that might contribute to the therapeutic effects of elevated muscle PGC-1α in different models of muscle wasting.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1186/s13395-016-0110-x
- PMID 27833743
- Persistent URL
- https://sonar.ch/global/documents/159971
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