Journal article
Three-year follow-up of human transplanted kidneys by diffusion-weighted MRI and blood oxygenation level-dependent imaging.
- Vermathen P Department of Clinical Research, University Hospital of Bern, Bern, Switzerland. Peter.Vermathen@insel.ch
- Binser T
- Boesch C
- Eisenberger U
- Thoeny HC
- 2011-12-20
Published in:
- Journal of magnetic resonance imaging : JMRI. - 2012
Adult
Aged
Diffusion Magnetic Resonance Imaging
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Image Enhancement
Image Interpretation, Computer-Assisted
Kidney Transplantation
Magnetic Resonance Imaging
Male
Middle Aged
Postoperative Complications
Prospective Studies
Statistics, Nonparametric
English
PURPOSE
To prospectively determine the 3-year stability and potential changes of functional parameters in renal allograft recipients obtained from diffusion-weighted imaging (DWI) and blood oxygenation level-dependent (BOLD) MRI.
MATERIALS AND METHODS
Nine renal allograft recipients underwent DWI and BOLD-MRI twice, once 7 ± 3 months after transplantation, and again 32 ± 2 months after the first MRI. DWI yielded an apparent diffusion coefficient (ADC) and the perfusion contribution (F(P) ). BOLD imaging yielded R2, providing an estimation of renal oxygenation. Coefficients of variation between (CV(b) ) and within subjects (CV(w) ) were calculated.
RESULTS
The parameters were stable after 32 months in eight of the nine patients, who had well-functioning allografts. Mean diffusion values were very similar in the first and second scan. CV(w) and CV(b) for ADC values were less than 3.5% and 5.9%, respectively, in cortex and medulla, but were higher for F(P) (15%-18%). CV(w) and CV(b) of R2 were also low (medulla: CV(w) = 10.8%, CV(b) = 11.4%; cortex: CV(w) and CV(b) = 7.2%). R2 increased significantly (P = 0.035) in cortex but not in medulla, suggesting reduced cortical oxygen content. One subject with decreased glomerular filtration rate demonstrated strongly altered parameters.
CONCLUSION
In the absence of graft dysfunction, DWI and BOLD imaging yield consistent results over 3 years in stable human renal allograft recipients.
To prospectively determine the 3-year stability and potential changes of functional parameters in renal allograft recipients obtained from diffusion-weighted imaging (DWI) and blood oxygenation level-dependent (BOLD) MRI.
MATERIALS AND METHODS
Nine renal allograft recipients underwent DWI and BOLD-MRI twice, once 7 ± 3 months after transplantation, and again 32 ± 2 months after the first MRI. DWI yielded an apparent diffusion coefficient (ADC) and the perfusion contribution (F(P) ). BOLD imaging yielded R2, providing an estimation of renal oxygenation. Coefficients of variation between (CV(b) ) and within subjects (CV(w) ) were calculated.
RESULTS
The parameters were stable after 32 months in eight of the nine patients, who had well-functioning allografts. Mean diffusion values were very similar in the first and second scan. CV(w) and CV(b) for ADC values were less than 3.5% and 5.9%, respectively, in cortex and medulla, but were higher for F(P) (15%-18%). CV(w) and CV(b) of R2 were also low (medulla: CV(w) = 10.8%, CV(b) = 11.4%; cortex: CV(w) and CV(b) = 7.2%). R2 increased significantly (P = 0.035) in cortex but not in medulla, suggesting reduced cortical oxygen content. One subject with decreased glomerular filtration rate demonstrated strongly altered parameters.
CONCLUSION
In the absence of graft dysfunction, DWI and BOLD imaging yield consistent results over 3 years in stable human renal allograft recipients.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1002/jmri.23537
- PMID 22180302
- Persistent URL
- https://sonar.ch/global/documents/162699
Statistics
Document views: 14
File downloads: