Back
The Central-European SentiMag study: sentinel lymph node biopsy with superparamagnetic iron oxide (SPIO) vs. radioisotope.
Journal article

The Central-European SentiMag study: sentinel lymph node biopsy with superparamagnetic iron oxide (SPIO) vs. radioisotope.

  • Thill M Department of Gynaecology and Obstetrics, Breast Cancer Centre, Agaplesion Markus Hospital, Frankfurt, Germany. Electronic address: marc.thill@fdk.info.
  • Kurylcio A Department of Surgical Oncology, Medical University of Lublin, Poland.
  • Welter R Department of Gynecology and Obstetrics, Interdisciplinary Breast Centre, Kantonsspital Baden, Baden, Switzerland.
  • van Haasteren V Department of Gynaecology and Obstetrics, Breast Cancer Centre, Agaplesion Markus Hospital, Frankfurt, Germany.
  • Grosse B Department of Gynaecology and Obstetrics, Breast Cancer Centre, Agaplesion Markus Hospital, Frankfurt, Germany.
  • Berclaz G Breast Centre Bern, Engeriedspital, Lindenhofgruppe, Bern, Switzerland.
  • Polkowski W Department of Surgical Oncology, Medical University of Lublin, Poland.
  • Hauser N Department of Gynecology and Obstetrics, Interdisciplinary Breast Centre, Kantonsspital Baden, Baden, Switzerland.
Show more…
  • 2014-02-04
Published in:
  • Breast (Edinburgh, Scotland). - 2014
Invasive breast cancer
SentiMag(®)
Sentinel lymph node biopsy
Sienna+(®)
Superparamagnetic iron oxide (SPIO)
Adult
Aged
Aged, 80 and over
Axilla
Breast Neoplasms
Contrast Media
Dextrans
Female
Humans
Lymph Nodes
Lymphatic Metastasis
Magnetite Nanoparticles
Middle Aged
Prospective Studies
Radionuclide Imaging
Radiopharmaceuticals
Sentinel Lymph Node Biopsy
Technetium Tc 99m Aggregated Albumin
English Sentinel lymph node biopsy (SLNB) is the standard surgical procedure for the axilla in early node-negative breast cancer. To date, the "gold standard" to localize the sentinel lymph node (SLN) is the radiotracer (99m)Tc with or without blue dye. The aim of this study was to evaluate potential equivalency of the new SentiMag(®) technique in comparison to the "gold standard". Within this prospective, multicentric and multinational non-inferiority study including 150 patients (99m)Tc was compared with the magnetic technique, using superparamagnetic iron oxide particles (SPIOs, Sienna+(®)) for localization of SLNs. The results showed a detection rate per patient of 97.3% (146/150) for (99m)Tc vs. 98.0% (147/150) for Sienna+(®) with a similar average number of removed SLNs per patient and a higher per patient malignancy detection rate for the SPIO tracer. We obtained convincing results that magnetic SLNB can be performed easily, safely and equivalently well in comparison to the radiotracer method.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/163675
Statistics
Document views: 34 File downloads: