Journal article
Time to remission from mild to moderate depressive symptoms: One year results from the EVIDENT-study, an RCT of an internet intervention for depression.
- Klein JP Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany. Electronic address: philipp.klein@uksh.de.
- Späth C Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany.
- Schröder J Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- Meyer B GAIA AG, Hamburg, Germany; Department of Psychology, City, University of London, London, United Kingdom.
- Greiner W Department of Health Economics and Health Care Management, Bielefeld University, Bielefeld, Germany.
- Hautzinger M Eberhard Karls University Tübingen, Department of Psychology, Clinical Psychology and Psychotherapy, Tübingen, Germany.
- Lutz W Department of Psychology, University of Trier, Germany.
- Rose M Department of Psychosomatic Medicine, Charité University Medical Center, Berlin, Germany; Quantitative Health Sciences, Outcomes Measurement Science, University of Massachusetts Medical School, Worcester, MA, USA.
- Vettorazzi E Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- Andersson G Department of Behavioural Sciences and Learning, Linköping University, Linköping, Sweden; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
- Hohagen F Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany.
- Moritz S Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- Berger T Department of Clinical Psychology and Psychotherapy, University of Bern, Bern, Switzerland.
- 2017-08-12
Published in:
- Behaviour research and therapy. - 2017
Cognitive behavior therapy
Depression
Internet intervention
One year follow-up
Randomized controlled trial
Remission
Adolescent
Adult
Aged
Antidepressive Agents
Cognitive Behavioral Therapy
Combined Modality Therapy
Depression
Female
Humans
Internet
Male
Middle Aged
Remission Induction
Single-Blind Method
Time Factors
Young Adult
English
BACKGROUND
Internet interventions are effective in treating depressive symptoms but few studies conducted a long-term follow-up. The aim of this study was to test the effectiveness of an internet intervention in increasing the remission rate over a twelve months period.
METHODS
A total of 1013 participants with mild to moderate depressive symptoms were randomized to either care as usual alone or a 12-week internet intervention (Deprexis) plus usual care. Self-rated depression severity (PHQ-9) was assessed regularly over twelve months.
RESULTS
Remission rates over time were significantly higher in the intervention group (Cox regression: hazard ratio [HR] 1.31; p = 0.009). The intervention was more effective in the subgroup not taking antidepressant medication (Cox regression: HR 1.88; p < 0.001). PHQ-change from baseline was greater in the intervention group (linear mixed model [LMM]: p < 0.001) with the between-group effect gradually decreasing from d = 0.36 at three months to d = 0.13 at twelve months (LMM: group by time interaction: p < 0.001).
CONCLUSION
This internet intervention can contribute to achieving remission in people with mild to moderate depressive symptoms, especially if they are not on antidepressant medication (Trial Registration: NCT01636752).
Internet interventions are effective in treating depressive symptoms but few studies conducted a long-term follow-up. The aim of this study was to test the effectiveness of an internet intervention in increasing the remission rate over a twelve months period.
METHODS
A total of 1013 participants with mild to moderate depressive symptoms were randomized to either care as usual alone or a 12-week internet intervention (Deprexis) plus usual care. Self-rated depression severity (PHQ-9) was assessed regularly over twelve months.
RESULTS
Remission rates over time were significantly higher in the intervention group (Cox regression: hazard ratio [HR] 1.31; p = 0.009). The intervention was more effective in the subgroup not taking antidepressant medication (Cox regression: HR 1.88; p < 0.001). PHQ-change from baseline was greater in the intervention group (linear mixed model [LMM]: p < 0.001) with the between-group effect gradually decreasing from d = 0.36 at three months to d = 0.13 at twelve months (LMM: group by time interaction: p < 0.001).
CONCLUSION
This internet intervention can contribute to achieving remission in people with mild to moderate depressive symptoms, especially if they are not on antidepressant medication (Trial Registration: NCT01636752).
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.brat.2017.07.013
- PMID 28797829
- Persistent URL
- https://sonar.ch/global/documents/169885
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