Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature.
- Konieczka K Department of Ophthalmology, University of Basel, Basel, Switzerland.
- Koch S Department of Ophthalmology, University of Basel, Basel, Switzerland.
- Hauenstein D Department of Ophthalmology, University of Basel, Basel, Switzerland.
- Chackathayil TN Department of Ophthalmology, University of Basel, Basel, Switzerland.
- Binggeli T Department of Ophthalmology, University of Basel, Basel, Switzerland.
- Schoetzau A Department of Ophthalmology, University of Basel, Basel, Switzerland.
- Flammer J Department of Ophthalmology, University of Basel, Basel, Switzerland.
- 2019-07-02
Published in:
- Translational vision science & technology. - 2019
brimonidine
corneal temperature
glaucoma
healthy subjects
latanoprost
ocular blood flow
ocular surface thermography
English
Purpose
The aim of this study was to investigate the effects of the glaucoma drugs latanoprost, brimonidine, and the combination of both on the central corneal temperature (CT) of healthy subjects by means of infrared thermography. Changes of the central CT may reflect changes of ocular blood flow.
Methods
Before application and during 2 hours after the application of latanoprost, brimonidine, or the combination of both in one eye, the CT in both eyes of 40 healthy subjects was measured repeatedly.
Results
Brimonidine reduced CT by approximately 0.5°C. This effect was statistically significant (P < 0.0001). Latanoprost, however, had a very small and insignificant influence (P = 0.47). Accordingly, the combination of brimonidine and latanoprost also reduced CT up to 0.5°C, and this effect was statistically significant (P < 0.0001).
Conclusions
Brimonidine, but not latanoprost, had a significant effect on central CT. This cooling effect of brimonidine is most probably due to a drug-induced reduction of blood circulation in the ciliary body and iris and to a certain extent also to a reduction of blood flow in the fundus of the eye.
Translational Relevance
This study shows evidence that thermography of the cornea provides indirect information on the influence of drugs on the blood flow to the anterior segment of the patient's eye.
The aim of this study was to investigate the effects of the glaucoma drugs latanoprost, brimonidine, and the combination of both on the central corneal temperature (CT) of healthy subjects by means of infrared thermography. Changes of the central CT may reflect changes of ocular blood flow.
Methods
Before application and during 2 hours after the application of latanoprost, brimonidine, or the combination of both in one eye, the CT in both eyes of 40 healthy subjects was measured repeatedly.
Results
Brimonidine reduced CT by approximately 0.5°C. This effect was statistically significant (P < 0.0001). Latanoprost, however, had a very small and insignificant influence (P = 0.47). Accordingly, the combination of brimonidine and latanoprost also reduced CT up to 0.5°C, and this effect was statistically significant (P < 0.0001).
Conclusions
Brimonidine, but not latanoprost, had a significant effect on central CT. This cooling effect of brimonidine is most probably due to a drug-induced reduction of blood circulation in the ciliary body and iris and to a certain extent also to a reduction of blood flow in the fundus of the eye.
Translational Relevance
This study shows evidence that thermography of the cornea provides indirect information on the influence of drugs on the blood flow to the anterior segment of the patient's eye.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1167/tvst.8.3.47
- PMID 31259092
- Persistent URL
- https://sonar.ch/global/documents/170834
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