A comprehensive framework for physiologically based pharmacokinetic modelling in Matlab®.
- Stader F Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
- Penny MA Infectious Disease Modelling Unit, Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
- Siccardi M Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
- Marzolini C Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
- 2019-02-20
Published in:
- CPT: pharmacometrics & systems pharmacology. - 2019
English
Physiologically based pharmacokinetic (PBPK) models are useful tools to predict clinical scenarios for special populations for whom there are high hurdles to conduct clinical trials such as children or the elderly. However, coding of a PBPK model in a mathematical programming language can be challenging. This tutorial illustrates how to build a whole-body PBPK model in Matlab® to answer specific pharmacological questions involving drug disposition, and magnitudes of drug-drug interactions in different patient populations. This article is protected by copyright. All rights reserved.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1002/psp4.12399
- PMID 30779335
- Persistent URL
- https://sonar.ch/global/documents/170849
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