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Journal article

Cross-Regulation of an Artificial Metalloenzyme.

  • Okamoto Y Department of Chemistry, University of Basel, Spitalstrasse 51, 4056, Basel, Switzerland.
  • Ward TR Department of Chemistry, University of Basel, Spitalstrasse 51, 4056, Basel, Switzerland.
  • 2017-05-10
Published in:
  • Angewandte Chemie (International ed. in English). - 2017
artificial metalloenzymes
biocatalysis
cross-regulation
hydrogenation
urease
Ammonia
Biocatalysis
Biomimetics
Canavalia
Enrofloxacin
Hydrogen-Ion Concentration
Hydrogenase
Metalloproteins
Urea
Urease
English Cross-regulation of complex biochemical reaction networks is an essential feature of living systems. In a biomimetic spirit, we report on our efforts to program the temporal activation of an artificial metalloenzyme via cross-regulation by a natural enzyme. In the presence of urea, urease slowly releases ammonia that reversibly inhibits an artificial transfer hydrogenase. Addition of an acid, which acts as fuel, allows to maintain the system out of equilibrium.
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  • English
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hybrid
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https://sonar.ch/global/documents/173971
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