Journal article
From intra- to extracellular vesicles: extracellular vesicles in developmental signalling
- Gradilla, Ana-Citlali Centro de Biología Molecular ‘Severo Ochoa’ (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, Spain
- Simon, Eléanor Centro de Biología Molecular ‘Severo Ochoa’ (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, Spain
- Aguilar, Gustavo Growth and Development, Biozentrum, University of Basel, Basel, Switzerland
- Guerrero, Isabel Centro de Biología Molecular ‘Severo Ochoa’ (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, Spain
- 2018-5-15
Published in:
- Essays in Biochemistry. - Portland Press Ltd.. - 2018, vol. 62, no. 2, p. 215-223
English
Signalling from cell-to-cell is fundamental for determining differentiation and patterning. This communication can occur between adjacent and distant cells. Extracellular vesicles (EVs) are membrane-based structures thought to facilitate the long-distance movement of signalling molecules. EVs have recently been found to allow the transport of two major developmental signalling pathways: Hedgehog and Wnt. These signalling molecules undergo crucial post-translational lipid modifications, which anchor them to membranes and impede their free release into the extracellular space. Preparation of these ligands in EVs involves intracellular vesicle sorting in an endocytosis-dependent recycling process before secretion. In the present review, we discuss the most recent advances with regard to EV involvement in developmental signalling at a distance. We focus on the role of the protein complexes involved in EV genesis, and provide a comprehensive perspective of the contribution of these complexes to intracellular vesicle sorting of developmental signals for their extracellular secretion, reception and transduction.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1042/ebc20180001
- ISSN 0071-1365
- Persistent URL
- https://sonar.ch/global/documents/174154
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