Biomechanics in bone tissue engineering.
- Pioletti DP Laboratory of Biomechanical Orthopedics, EPFL, Lausanne, Switzerland. dominique.pioletti@epfl.ch
- 2010-05-15
Published in:
- Computer methods in biomechanics and biomedical engineering. - 2010
English
Biomechanics may be considered as central in the development of bone tissue engineering. The initial mechanical aspects are essential to the outcome of a functional tissue engineering approach; so are aspects of interface micromotion, bone ingrowths inside the scaffold and finally, the mechanical integrity of the scaffold during its degradation. A proposed view is presented herein on how biomechanical aspects can be synthesised and where future developments are needed. In particular, a distinction is made between the mechanical and the mechanotransductional aspects of bone tissue engineering: the former could be related to osteoconduction, while the latter may be correlated to the osteoinductive properties of the scaffold. This distinction allows biomechanicians to follow a strategy in the development of a scaffold having not only mechanical targets but also incorporating some mechanotransduction principles.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1080/10255841003630660
- PMID 20467959
- Persistent URL
- https://sonar.ch/global/documents/176817
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