Pathogenesis of cutaneous lymphomas.

Dummer R; Willers J; Kamarashev J; Urosevic M; Döbbeling U; Burg G

doi:10.1016/s1085-5629(00)80003-6

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Journal article

Pathogenesis of cutaneous lymphomas.

Dummer R Department of Dermatology, University of Zürich Medical School, Switzerland.
Willers J
Kamarashev J
Urosevic M
Döbbeling U
Burg G

2000-07-13

Published in:

Seminars in cutaneous medicine and surgery. - 2000

Cell Transformation, Neoplastic

English Cutaneous lymphomas are a heterogeneous group of lymphoproliferative disorders derived from T cells, B cells and, in rare cases, natural killer cells. The precise mechanisms of the lymphomagenesis are still obscure. However, there are various factors involved. These factors include environmental, especially infectious factors, translocations, mutations and genetic instability. The special microenvironment in the skin is responsible for the peculiar behavior of these neoplasms by providing various key factors, such as adhesion molecules and cytokines. Newly identified molecular disturbances in cutaneous lymphomas might be targeted by specific molecular or immunologic interventions in the future.

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