Receptors of anthrax toxin and cell entry.
- van der Goot G Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, SV-AI Extension, Station 15, 1015 Lausanne, Switzerland. gisou.vandergoot@epfl.ch
- Young JA
- 2009-09-08
Published in:
- Molecular aspects of medicine. - 2009
Adaptor Proteins, Signal Transducing
Animals
Antigens, Bacterial
Bacillus anthracis
Bacterial Toxins
Endocytosis
Endosomes
GTPase-Activating Proteins
Humans
Hydrogen-Ion Concentration
Low Density Lipoprotein Receptor-Related Protein-6
Models, Molecular
Protein Conformation
Protein Subunits
Receptors, LDL
Receptors, Peptide
English
Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cellular receptors, and how receptor-type can dictate the low pH threshold of PA pore formation. The roles played by cellular factors in regulating the endocytosis of toxin-receptor complexes is also discussed.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1016/j.mam.2009.08.007
- PMID 19732789
- Persistent URL
- https://sonar.ch/global/documents/180371
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