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Journal article

Pathogenesis of arenavirus hemorrhagic fevers.

  • Moraz ML Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland.
  • Kunz S
  • 2010-12-22
Published in:
  • Expert review of anti-infective therapy. - 2011
Animals
Antiviral Agents
Arenaviridae Infections
Arenavirus
Cricetinae
Disease Models, Animal
Guinea Pigs
Hemorrhagic Fevers, Viral
Humans
Mice
English Viral hemorrhagic fevers (VHFs) caused by arenaviruses belong to the most devastating emerging human diseases and represent serious public health problems. Arenavirus VHFs in humans are acute diseases characterized by fever and, in severe cases, different degrees of hemorrhages associated with a shock syndrome in the terminal stage. Over the past years, much has been learned about the pathogenesis of arenaviruses at the cellular level, in particular their ability to subvert the host cell's innate antiviral defenses. Clinical studies and novel animal models have provided important new information about the interaction of hemorrhagic arenaviruses with the host's adaptive immune system, in particular virus-induced immunosuppression, and have provided the first hints towards an understanding of the terminal hemorrhagic shock syndrome. The scope of this article is to review our current knowledge on arenavirus VHF pathogenesis with an emphasis on recent developments.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.ch/global/documents/181316
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