Journal article
Eosinophilic myositis/perimyositis: frequency and spectrum of cutaneous manifestations.
- Trüeb RM Department of Dermatology, University Hospital of Zurich, Switzerland.
- Pericin M
- Winzeler B
- Wüthrich B
- Burg G
- 1997-10-06
Published in:
- Journal of the American Academy of Dermatology. - 1997
Adult
Aged
Eosinophilia
Female
Humans
Hypereosinophilic Syndrome
Male
Middle Aged
Muscle, Skeletal
Myositis
Skin
Skin Diseases
English
BACKGROUND
Eosinophilic myositis/perimyositis (EM/P) are a group of rare idiopathic muscle disorders associated with eosinophilia.
OBJECTIVE
We describe the frequency and spectrum of cutaneous manifestations in EM/P and compare them with the idiopathic hypereosinophilic syndrome (HES).
METHODS
We review the literature on EM/P and describe an additional case associated with angioedema.
RESULTS
Of a total of 26 reported patients with EM/P, cutaneous manifestations were observed in 10. These were, in order of frequency, deep subcutaneous induration, erythema, angioedema, urticaria, and papular lesions.
CONCLUSION
Skin lesions occur less frequently in EM/P than in HES. Although erythematous papulonodular lesions and urticaria/angioedema are most commonly observed in HES, the most frequent skin manifestations of EM/P are subcutaneous induration and erythema. In HES, angioedema has been correlated with a favorable prognosis. At least some of these patients apparently have an idiopathic eosinophilic disorder distinct from HES, including EM/P. In contrast to HES, the overall prognosis of EM/P is good, particularly when muscle lesions are focal, and the principal histopathologic finding is perimysial infiltrates.
Eosinophilic myositis/perimyositis (EM/P) are a group of rare idiopathic muscle disorders associated with eosinophilia.
OBJECTIVE
We describe the frequency and spectrum of cutaneous manifestations in EM/P and compare them with the idiopathic hypereosinophilic syndrome (HES).
METHODS
We review the literature on EM/P and describe an additional case associated with angioedema.
RESULTS
Of a total of 26 reported patients with EM/P, cutaneous manifestations were observed in 10. These were, in order of frequency, deep subcutaneous induration, erythema, angioedema, urticaria, and papular lesions.
CONCLUSION
Skin lesions occur less frequently in EM/P than in HES. Although erythematous papulonodular lesions and urticaria/angioedema are most commonly observed in HES, the most frequent skin manifestations of EM/P are subcutaneous induration and erythema. In HES, angioedema has been correlated with a favorable prognosis. At least some of these patients apparently have an idiopathic eosinophilic disorder distinct from HES, including EM/P. In contrast to HES, the overall prognosis of EM/P is good, particularly when muscle lesions are focal, and the principal histopathologic finding is perimysial infiltrates.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/s0190-9622(97)70136-1
- PMID 9308550
- Persistent URL
- https://sonar.ch/global/documents/185653
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