Association between dietary intake and inflammatory markers: results from the CoLaus study.
- Piccand E 1Department of Medicine,Internal Medicine,Lausanne University Hospital,Rue du Bugnon 46,1011Lausanne,Switzerland.
- Vollenweider P 1Department of Medicine,Internal Medicine,Lausanne University Hospital,Rue du Bugnon 46,1011Lausanne,Switzerland.
- Guessous I 2Department of Ambulatory Care and Community Medicine,University of Lausanne,Lausanne,Switzerland.
- Marques-Vidal P 1Department of Medicine,Internal Medicine,Lausanne University Hospital,Rue du Bugnon 46,1011Lausanne,Switzerland.
- 2018-10-19
Published in:
- Public health nutrition. - 2019
Dietary patterns
Dietary scores
Epidemiology
Inflammation
Nutrients
Aged
Biomarkers
C-Reactive Protein
Cross-Sectional Studies
Cytokines
Diet
Diet Surveys
Feeding Behavior
Female
Humans
Inflammation
Leukocyte Count
Male
Middle Aged
Nutritive Value
Switzerland
English
OBJECTIVE
To assess the associations between single foods, nutrients, dietary patterns and dietary scores, and inflammatory markers (C-reactive protein (CRP), IL-6, TNF-α and leucocyte count).
DESIGN
Cross-sectional, population-based study.
SETTING
City of Lausanne, Switzerland, years 2009-2012.
SUBJECTS
Adults (n 4027; 46·5 % men), mean age 57·2 (sd 10·2) years. Dietary intake was collected using a semi-quantitative FFQ. Single foods and nutrients, three dietary patterns ('Meat & fries'; 'Fruits & vegetables'; 'Fatty & sugary') and three dietary scores (two Mediterranean; Alternative Healthy Eating Index (AHEI)) were used. Associations were assessed using correlation and multivariable linear regression.
RESULTS
After adjusting for total energy intake, gender and other sociodemographic factors, no individual macro- or micronutrient was associated with inflammatory markers. Among single foods, only fruit intake was negatively associated with CRP levels (standardized regression score=-0·043, P<0·01). The 'Fruits & vegetables' pattern, the Mediterranean and the AHEI scores were negatively associated with CRP levels (standardized regression score=-0·079, -0·043 and -0·067, respectively, all P<0·01). When entered simultaneously with fruit intake, the 'Fruits & vegetables' pattern, the Mediterranean and the AHEI scores tended to remain significantly and negatively associated with CRP levels, while the association with fruit intake was no longer significant. No association between all dietary markers and IL-6, TNF-α or leucocyte count was found.
CONCLUSIONS
Dietary scores, but not individual foods, are associated with inflammatory markers in the general population.
To assess the associations between single foods, nutrients, dietary patterns and dietary scores, and inflammatory markers (C-reactive protein (CRP), IL-6, TNF-α and leucocyte count).
DESIGN
Cross-sectional, population-based study.
SETTING
City of Lausanne, Switzerland, years 2009-2012.
SUBJECTS
Adults (n 4027; 46·5 % men), mean age 57·2 (sd 10·2) years. Dietary intake was collected using a semi-quantitative FFQ. Single foods and nutrients, three dietary patterns ('Meat & fries'; 'Fruits & vegetables'; 'Fatty & sugary') and three dietary scores (two Mediterranean; Alternative Healthy Eating Index (AHEI)) were used. Associations were assessed using correlation and multivariable linear regression.
RESULTS
After adjusting for total energy intake, gender and other sociodemographic factors, no individual macro- or micronutrient was associated with inflammatory markers. Among single foods, only fruit intake was negatively associated with CRP levels (standardized regression score=-0·043, P<0·01). The 'Fruits & vegetables' pattern, the Mediterranean and the AHEI scores were negatively associated with CRP levels (standardized regression score=-0·079, -0·043 and -0·067, respectively, all P<0·01). When entered simultaneously with fruit intake, the 'Fruits & vegetables' pattern, the Mediterranean and the AHEI scores tended to remain significantly and negatively associated with CRP levels, while the association with fruit intake was no longer significant. No association between all dietary markers and IL-6, TNF-α or leucocyte count was found.
CONCLUSIONS
Dietary scores, but not individual foods, are associated with inflammatory markers in the general population.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1017/S1368980018002355
- PMID 30333073
- Persistent URL
- https://sonar.ch/global/documents/186194
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