![Specific, uncompetitive inhibition of beta-galactosidases by a 5,6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol derivative.](/static/images/no-image.png)
Journal article
Specific, uncompetitive inhibition of beta-galactosidases by a 5,6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol derivative.
- Schaller C Institut de chimie organique de l'Université de Lausanne, Lausanne-Dorigny, Switzerland.
- Demange R
- Picasso S
- Vogel P
- 1999-02-18
Published in:
- Bioorganic & medicinal chemistry letters. - 1999
Aspergillus
Dose-Response Relationship, Drug
Furans
Hydrogen-Ion Concentration
Hydrolysis
Inhibitory Concentration 50
Isoxazoles
Magnetic Resonance Spectroscopy
beta-Galactosidase
English
(-)-(3aS,5S,6S.6aR)-3a,5,6,6a-Tetrahydro-5,6-isopropylide nedioxyfuro [2,3-d]isoxazole-3-methanol ((-)-5) has been tested toward 25 glycohydrolases and found to inhibit beta-galactosidase from Aspergillus niger (Ki = 18 microM) and that from Aspergillus orizae (Ki = 72 microM). Hydrolysis of the acetonide or exchange of CH2OH group for a CHO, CH2OMe or a CH2OMOM group suppresses the inhibitory activity.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/s0960-894x(98)00722-7
- PMID 10021944
- Persistent URL
- https://sonar.ch/global/documents/189439
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