Journal article
CD4+CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5.
- Finke D Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland. dfinke@isrec.unil.ch
- Acha-Orbea H
- Mattis A
- Lipp M
- Kraehenbuhl J
- 2002-10-02
Published in:
- Immunity. - 2002
Adoptive Transfer
Animals
CD3 Complex
CD4-Positive T-Lymphocytes
Cell Adhesion
Chemokine CXCL13
Chemokines, CXC
Immunologic Deficiency Syndromes
Integrin alpha4beta1
Mice
Mice, Inbred C57BL
Mice, Knockout
Models, Immunological
Morphogenesis
Peyer's Patches
Radiation Chimera
Receptors, CXCR5
Receptors, Chemokine
Receptors, Cytokine
Signal Transduction
Stromal Cells
Vascular Cell Adhesion Molecule-1
English
CD4+CD3- cells are the predominant hematopoietic cells found in mouse fetal intestine. We prove their role as Peyer's patch (PP)-inducing cells by transfer into neonatal PP-deficient mice. To test the requirement of chemokines and adhesion molecules in induction of PP, we studied mice deficient in CXCR5 and/or alpha4beta1 integrin-mediated adhesion. CXCR5-/- mice have CD4+CD3- cells, which are inefficient in inducing PP formation. We show here that CXCR5/CXCL13 signaling activates alpha4beta1 integrin on CD4+CD3- cells. Blocking of beta1 integrin or VCAM-1, the ligand of alpha4beta1 integrin, inhibits PP formation. This study demonstrates the link between chemokine receptors and adhesion molecules that regulates stromal/hematopoietic cell interaction leading to PP formation.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/s1074-7613(02)00395-3
- PMID 12354388
- Persistent URL
- https://sonar.ch/global/documents/189473
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