MARK-AGE biomarkers of ageing.

Bürkle A; Moreno-Villanueva M; Bernhard J; Blasco M; Zondag G; Hoeijmakers JH; Toussaint O; Grubeck-Loebenstein B; Mocchegiani E; Collino S; Gonos ES; Sikora E; Gradinaru D; Dollé M; Salmon M; Kristensen P; Griffiths HR; Libert C; Grune T; Breusing N; Simm A; Franceschi C; Capri M; Talbot D; Caiafa P; Friguet B; Slagboom PE; Hervonen A; Hurme M; Aspinall R

doi:10.1016/j.mad.2015.03.006

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Journal article

MARK-AGE biomarkers of ageing.

Bürkle A Molecular Toxicology Group, Department of Biology, Box 628, University of Konstanz, 78457 Konstanz, Germany. Electronic address: alexander.buerkle@uni-konstanz.de.
Moreno-Villanueva M Molecular Toxicology Group, Department of Biology, Box 628, University of Konstanz, 78457 Konstanz, Germany.
Bernhard J BioTeSys GmbH, 73728 Esslingen, Germany.
Blasco M Spanish National Cancer Research Centre (CNIO), 3 Melchor Fernandez Almagro, 28029 Madrid, Spain.
Zondag G DNage BV(1), Leiden, The Netherlands.
Hoeijmakers JH Department of Genetics, Erasmus University Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.
Toussaint O University of Namur, Research Unit on Cellular Biology, Rue de Bruxelles, 61, Namur B-5000, Belgium.
Grubeck-Loebenstein B Research Institute for Biomedical Aging Research, University of Innsbruck, Rennweg, 10, 6020 Innsbruck, Austria.
Mocchegiani E Translational Research Center of Nutrition and Ageing, IRCCS-INRCA, Via Birarelli 8, 60121 Ancona, Italy.
Collino S Nestlé Institute of Health Sciences SA, Molecular Biomarkers, EPFL Innovation Park, 1015 Lausanne, Switzerland.
Gonos ES National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece.
Sikora E Laboratory of the Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur street, 02-093 Warsaw, Poland.
Gradinaru D Ana Aslan - National Institute of Gerontology and Geriatrics, Bucharest, Romania.
Dollé M National Institute for Public Health and the Environment (RIVM), Centre for Prevention and Health Services Research, P.O. Box 1, 3720 BA Bilthoven, The Netherlands.
Salmon M Straticell, Science Park Crealys, Rue Jean Sonet 10, 5032 Les Isnes, Belgium.
Kristensen P Department of Engineering - BCE Protein Engineering, Gustav Wiedsvej 10, 8000 Aarhus, Denmark.
Griffiths HR Life and Health Sciences, Aston Research Centre for Healthy Ageing, Aston University, Birmingham, UK.
Libert C Department for Molecular Biomedical Research, VIB, Ghent, Belgium.
Grune T Institute of Nutritional Medicine, University of Hohenheim, 70593 Stuttgart, Germany; Department of Nutritional Toxicology, Friedrich Schiller University Jena, Dornburger Str. 24, 07743 Jena, Germany.
Breusing N Institute of Nutritional Medicine, University of Hohenheim, 70593 Stuttgart, Germany.
Simm A Department of Cardiothoracic Surgery, University Hospital Halle, Ernst-Grube Str. 40, 06120 Halle (Saale), Germany.
Franceschi C CIG-Interdepartmental Center "L.Galvani", Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
Capri M CIG-Interdepartmental Center "L.Galvani", Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
Talbot D Unilever Corporate Research, Sharnbrook, UK.
Caiafa P Department of Cellular Biotechnologies and Hematology, Faculty of Pharmacy and Medicine, "Sapienza" University Rome, V.le Regina Elena 324, 00161 Rome, Italy.
Friguet B Sorbonne Universités, UPMC Univ Paris 06, UMR UPMC CNRS 8256, Biological adaptation and ageing - IBPS, INSERM U1164, F-75005 Paris, France.
Slagboom PE Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands.
Hervonen A Medical School, University of Tampere, 33014 Tampere, Finland.
Hurme M Medical School, University of Tampere, 33014 Tampere, Finland.
Aspinall R Regenerative Medicine Group, Cranfield Health, Cranfield, UK.

2015-03-31

Published in:

Mechanisms of ageing and development. - 2015

English Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

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