Journal article
A prospective, multisite, international validation of the Complex Regional Pain Syndrome Severity Score.
- Harden RN aRehabilitation Institute of Chicago, Chicago, IL, USA bUniversity of Erlangen-Nuremberg, Erlangen, Germany cReuth Rehabilitation Hospital, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel dVU University Medical Center Amsterdam, Institute for Health and Care Research, Amsterdam, the Netherlands eBalgrist University, Zurich, Switzerland fCleveland Clinic, Cleveland, OH, USA gDepartment of Neurology, Leiden University Medical Center, Leiden, the Netherlands hStanford University Medical Center, Stanford, CA, USA iUniversity Medical Center Mainz, Mainz, Germany jUniversity Health Network, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada kVanderbilt University School of Medicine, Nashville, TN, USA.
- Maihofner C
- Abousaad E
- Vatine JJ
- Kirsling A
- Perez RSGM
- Kuroda M
- Brunner F
- Stanton-Hicks M
- Marinus J
- van Hilten JJ
- Mackey S
- Birklein F
- Schlereth T
- Mailis-Gagnon A
- Graciosa J
- Connoly SB
- Dayanim D
- Massey M
- Frank H
- Livshitz A
- Bruehl S
- 2017-07-18
Published in:
- Pain. - 2017
Adult
Aged
Complex Regional Pain Syndromes
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Pain
Pain Measurement
Prospective Studies
Severity of Illness Index
English
Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, a format necessary for clinical decision making. Such dichotomous diagnostic categories do not convey an individual's subtle gradations in the severity of the condition over time and have poor statistical power when used as an outcome measure in research. This prospective, international, multicenter study slightly modified and further evaluated the validity of the CRPS Severity Score (CSS), a continuous index of CRPS severity. Using a prospective design, medical evaluations were conducted in 156 patients with CRPS to compare changes over time in CSS scores between patients initiating a new treatment program and patients on stable treatment regimens. New vs stable categorizations were supported by greater changes in pain and function in the former. Results indicated that CSS values in the stable CRPS treatment group exhibited much less change over time relative to the new treatment group, with intraclass correlations nearly twice as large in the former. A calculated smallest real difference value revealed that a change in the CSS of ≥4.9 scale points would indicate real differences in CRPS symptomatology (with 95% confidence). Across groups, larger changes in CRPS features on the CSS over time were associated in the expected direction with greater changes in pain intensity, fatigue, social functioning, ability to engage in physical roles, and general well-being. The overall pattern of findings further supports the validity of the CSS as a measure of CRPS severity and suggests it may prove useful in clinical monitoring and outcomes research.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1097/j.pain.0000000000000927
- PMID 28715350
- Persistent URL
- https://sonar.ch/global/documents/191356
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