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Progressive crossed-apraxia of speech as a first manifestation of a probable corticobasal degeneration.
Journal article

Progressive crossed-apraxia of speech as a first manifestation of a probable corticobasal degeneration.

  • 2012-08-14
Published in:
  • Behavioural neurology. - 2012
Aged
Agraphia
Basal Ganglia
Basal Ganglia Diseases
Cerebral Cortex
Disease Progression
Female
Functional Laterality
Handwriting
Humans
Magnetic Resonance Imaging
Middle Aged
Neurodegenerative Diseases
Neuropsychological Tests
Positron-Emission Tomography
Psychomotor Performance
Speech Disorders
Tomography, X-Ray Computed
English We present the longitudinal neurolinguistic, neuropsychological and neurologic follow-up of a 64 y.o. right-handed woman, who developed progressive apraxia of speech (PAOS), followed by peripheral agraphia then a left corticobasal syndrome (CBS). Neuroimaging (CT, MRI and FDG-PET) unequivocally showed progressive right hemispheric atrophy and hypometabolism. This particular evolution first confirms that PAOS is a phenotype of probable corticobasal degeneration (CBD). More importantly, this case underpins the neural organisation of motor planning processing in relation with speech, as well as graphic and limb praxis impairments, and constitutes a rare example of crossed-PAOS.
Language
  • English
Identifiers
Persistent URL
https://sonar.ch/global/documents/191999
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