Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.

• Janouskova H Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
• El Tekle G Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
• Bellini E Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
• Udeshi ND Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
• Rinaldi A Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
• Ulbricht A Department of Biochemistry, Eidgenössische Technische Hochschule, Zurich, Switzerland.
• Bernasocchi T Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
• Civenni G Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
• Losa M Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
• Svinkina T Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
• Bielski CM Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
• Kryukov GV Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
• Cascione L Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
• Napoli S Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
• Enchev RI Department of Biochemistry, Eidgenössische Technische Hochschule, Zurich, Switzerland.
• Mutch DG Division of Gynecologic Oncology, Washington University, St. Louis, Missouri, USA.
• Carney ME Department of Obstetrics, Gynecology and Women’s Health, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
• Berchuck A Division of Gynecologic Oncology, Duke Cancer Center, Durham, North Carolina, USA.
• Winterhoff BJN Division of Gynecologic Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
• Broaddus RR Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
• Schraml P Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
• Moch H Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
• Bertoni F Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
• Catapano CV Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
• Peter M Department of Biochemistry, Eidgenössische Technische Hochschule, Zurich, Switzerland.
• Carr SA Department of Biochemistry, Eidgenössische Technische Hochschule, Zurich, Switzerland.
• Garraway LA Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
• Wild PJ Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
• Theurillat JP Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

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Acetanilides

Adenocarcinoma, Clear Cell

Animals

Apoptosis

Azepines

Carcinoma, Endometrioid

Carcinosarcoma

Cell Cycle Proteins

Cell Line, Tumor

Cell Proliferation

Chromatography, Liquid

Cullin Proteins

Drug Resistance, Neoplasm

Endometrial Neoplasms

Epigenesis, Genetic

Female

Heterocyclic Compounds, 3-Ring

Humans

Immunoblotting

Immunohistochemistry

Immunoprecipitation

Male

Mass Spectrometry

Mice, Nude

Molecular Targeted Therapy

Mutation

Neoplasm Transplantation

Neoplasms, Cystic, Mucinous, and Serous

Nuclear Proteins

Prostatic Neoplasms

Protein-Serine-Threonine Kinases

RNA-Binding Proteins

Repressor Proteins

Reverse Transcriptase Polymerase Chain Reaction

Transcription Factors

Triazoles

Ubiquitination