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Exposure of Children to Rural Lifestyle Factors Associated With Protection Against Allergies Induces an Anti-Neu5Gc Antibody Response.

  • Frei R Christine Kuehne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
  • Roduit C Christine Kuehne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
  • Ferstl R Christine Kuehne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
  • O'Mahony L Departments of Medicine and Microbiology, APC Microbiome Ireland, University College Cork, Cork, Ireland.
  • Lauener RP Christine Kuehne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
  • 2019-08-06
Published in:
  • Frontiers in immunology. - 2019
N-glycolylneuraminic acid
animal contact
anti-inflammatory
asthma
hygiene hypothesis
regulatory T cells
Allergens
Animals
Antibodies, Monoclonal
Antibody Formation
Asthma
Cats
Humans
Hypersensitivity
Immunoglobulin G
Inflammation
Life Style
Mice
Neuraminic Acids
English Rural lifestyle has been shown to be highly protective against the development of allergies. Contact to farm-animals or pets and early-life consumption of milk products turned out to be important. These exposures provide contact to N-glycolylneuraminic acid (Neu5Gc), a sialic acid naturally expressed in mammalians but not in humans or microbes although both are able to incorporate exogenously provided Neu5Gc and induce thereby an anti-Neu5Gc antibody response. Farmers' children had elevated levels of anti-Neu5Gc antibodies associated with increased contact to Neu5Gc. Farm-related exposures that were associated with protection against allergies such as exposure to farm-animals or pets and consumption of milk were also associated with an antibody response to Neu5Gc in children. Exposure to cats was associated with increased anit-Neu5Gc IgG levels at different timepoints assessed between 1 year of age and school-age. Moreover, consumption of non-pasteurized milk in the first year of life was associated with increased anti-Neu5Gc IgG levels. Neu5Gc-providing exposures that were associated with protection against allergies were reflected in an elevated anti-Neu5Gc IgG level in children. Exposure to Neu5Gc was associated with anti-inflammation and protection of asthma development in children and mice without contribution of anti-Neu5Gc antibodies.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/200999
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