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The Immunology of CD1- and MR1-Restricted T Cells.
Journal article

The Immunology of CD1- and MR1-Restricted T Cells.

  • Mori L Department of Biomedicine, Basel University Hospital and Basel University, CH-4031 Basel, Switzerland; email: lucia.mori@unibas.ch , marco.lepore@unibas.ch , gennaro.delibero@unibas.ch.
  • Lepore M Department of Biomedicine, Basel University Hospital and Basel University, CH-4031 Basel, Switzerland; email: lucia.mori@unibas.ch , marco.lepore@unibas.ch , gennaro.delibero@unibas.ch.
  • De Libero G Department of Biomedicine, Basel University Hospital and Basel University, CH-4031 Basel, Switzerland; email: lucia.mori@unibas.ch , marco.lepore@unibas.ch , gennaro.delibero@unibas.ch.
  • 2016-03-02
Published in:
  • Annual review of immunology. - 2016
T cell receptor
antigen presentation
autoimmune diseases
infectious diseases
innate-like T cells
lipid antigens
metabolite antigens
mucosal-associated invariant T cells
natural killer T cells
tumor immunity
Animals
Antigen Presentation
Antigens
Antigens, CD1
Autoimmune Diseases
Histocompatibility Antigens Class I
Humans
Immunologic Surveillance
Infections
Killer Cells, Natural
Lymphocyte Activation
Minor Histocompatibility Antigens
Natural Killer T-Cells
Neoplasms
Protein Binding
Receptors, Antigen, T-Cell
English CD1- and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic antigens, such as lipids and small metabolites, and account for a major fraction of circulating and tissue-resident T cells. They represent a readily activated, long-lasting population of effector cells and contribute to the early phases of immune response, orchestrating the function of other cells. This review addresses the main aspects of their immunological functions, including antigen and T cell receptor repertoires, mechanisms of nonpeptidic antigen presentation, and the current evidence for their participation in human and experimental diseases.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/207416
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