Back
Full-text
Journal article

CD8+ T cells induce cachexia during chronic viral infection.

  • Baazim H CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Schweiger M Institute of Molecular Biosciences, University of Graz, Graz, Austria.
  • Moschinger M CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Xu H Department of Molecular Medicine II, Heinrich Heine University, Düsseldorf, Germany.
  • Scherer T Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
  • Popa A CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Gallage S Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.
  • Ali A Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.
  • Khamina K CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Kosack L CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Vilagos B CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Smyth M CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Lercher A CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Friske J Department of Biomedical Imaging and Image-guided Therapy, Division of Gender and Molecular Imaging, Preclinical Imaging Laboratory, Medical University of Vienna, Vienna, Austria.
  • Merkler D Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
  • Aderem A Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
  • Helbich TH Department of Biomedical Imaging and Image-guided Therapy, Division of Gender and Molecular Imaging, Preclinical Imaging Laboratory, Medical University of Vienna, Vienna, Austria.
  • Heikenwälder M Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.
  • Lang PA Department of Molecular Medicine II, Heinrich Heine University, Düsseldorf, Germany.
  • Zechner R Institute of Molecular Biosciences, University of Graz, Graz, Austria.
  • Bergthaler A CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. abergthaler@cemm.oeaw.ac.at.
Show more…
  • 2019-05-22
Published in:
  • Nature immunology. - 2019
Adipose Tissue
Animals
CD8-Positive T-Lymphocytes
Cachexia
Chronic Disease
Cytokines
Female
Interferon Type I
Lipid Metabolism
Lipolysis
Lymphocyte Activation
Lymphocytic choriomeningitis virus
Magnetic Resonance Imaging
Male
Mice
Signal Transduction
Virus Diseases
English Cachexia represents a leading cause of morbidity and mortality in various cancers, chronic inflammation and infections. Understanding of the mechanisms that drive cachexia has remained limited, especially for infection-associated cachexia (IAC). In the present paper we describe a model of reversible cachexia in mice with chronic viral infection and identify an essential role for CD8+ T cells in IAC. Cytokines linked to cancer-associated cachexia did not contribute to IAC. Instead, virus-specific CD8+ T cells caused morphologic and molecular changes in the adipose tissue, which led to depletion of lipid stores. These changes occurred at a time point that preceded the peak of the CD8+ T cell response and required T cell-intrinsic type I interferon signaling and antigen-specific priming. Our results link systemic antiviral immune responses to adipose-tissue remodeling and reveal an underappreciated role of CD8+ T cells in IAC.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.ch/global/documents/213780
Statistics
Document views: 82 File downloads:
  • Full-text: 0