Autophagy Proteins in Viral Exocytosis and Anti-Viral Immune Responses.
- Münz C Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. christian.muenz@uzh.ch.
- 2017-10-05
Published in:
- Viruses. - 2017
Epstein Barr virus
LAP (LC3 associated phagocytosis)
MHC class I molecules
MHC class II molecules
Varizella Zoster virus
coxsackie B virus
poliovirus
Antigen Presentation
Autophagy
Enterovirus B, Human
Exocytosis
Herpesvirus 3, Human
Herpesvirus 4, Human
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Humans
Poliovirus
Viral Proteins
Virus Activation
Virus Replication
Viruses
English
Abstract: Autophagy-related (Atg) gene-encoded proteins were originally described for their crucial role in macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes. Recently it has become clear that modules of this machinery can also be used to influence endo- and exocytosis. This mini review discusses how these alternative Atg functions support virus replication and viral antigen presentation on major histocompatibility (MHC) class I and II molecules. A better understanding of the modular use of the macroautophagy machinery might enable us to manipulate these alternative functions of Atg proteins during anti-viral therapies and to attenuate virus-induced immune pathologies.
- Language
-
- English
- Open access status
- gold
- Identifiers
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- DOI 10.3390/v9100288
- PMID 28976939
- Persistent URL
- https://sonar.ch/global/documents/21458
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