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The Modified Ottawa Score and Clinical Events in Hospitalized Patients with Cancer-Associated Thrombosis from the Swiss VTE Registry.
Journal article

The Modified Ottawa Score and Clinical Events in Hospitalized Patients with Cancer-Associated Thrombosis from the Swiss VTE Registry.

  • Alatri A Division of Angiology, Lausanne University Hospital, Lausanne, Switzerland.
  • Mazzolai L Division of Angiology, Lausanne University Hospital, Lausanne, Switzerland.
  • Kucher N Division of Vascular Medicine, Swiss Cardiovascular Center, Bern University Hospital, Bern, Switzerland.
  • Aujesky D Division of General Internal Medicine, Bern University Hospital, Bern, Switzerland.
  • Beer JH Department of Internal Medicine, Cantonal Hospital Baden, Baden, Switzerland.
  • Baldi T Department of Internal Medicine, University Hospital Basel, Basel, Switzerland.
  • Banyai M Department of Internal Medicine, Cantonal Hospital Lucerne, Lucerne, Switzerland.
  • Hayoz D Department of Internal Medicine, Cantonal Hospital Fribourg, Fribourg, Switzerland.
  • Kaeslin T Department of Internal Medicine, Cantonal Hospital Obwalden, Sarnen, Switzerland.
  • Korte W Department of Internal Medicine, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
  • Escher R Department of Internal Medicine, Regional Hospital Burgdorf, Burgdorf, Switzerland.
  • Husmann M Clinic of Angiology, University Hospital Zurich, Zurich, Switzerland.
  • Frauchiger B Department of Internal Medicine, Cantonal Hospital Frauenfeld, Frauenfeld, Switzerland.
  • Engelberger RP Division of Vascular Medicine, Swiss Cardiovascular Center, Bern University Hospital, Bern, Switzerland.
  • Baumgartner I Division of Vascular Medicine, Swiss Cardiovascular Center, Bern University Hospital, Bern, Switzerland.
  • Spirk D Institute of Pharmacology, University of Bern, Bern, Switzerland.
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  • 2017-08-05
Published in:
  • Seminars in thrombosis and hemostasis. - 2017
Aged
Aged, 80 and over
Anticoagulants
Female
Hospitalization
Humans
Inpatients
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasms
Prognosis
Recurrence
Registries
Thrombosis
Venous Thromboembolism
English AbstractThe modified Ottawa score (MOS) predicted venous thromboembolism (VTE) recurrence in a cohort of patients with cancer-associated thrombosis mainly managed on an outpatient basis. We aimed to assess the prognostic value of the MOS in hospitalized patients with cancer-associated thrombosis. In 383 hospitalized patients with cancer-associated VTE from the SWIss VTE Registry, 98 (25%) were classified as low risk, 175 (46%) as intermediate risk, and 110 (29%) as high risk for VTE recurrence based on the MOS. Clinical end points were recurrent VTE, fatal VTE, major bleeding, and overall mortality at 90 days. Overall, 179 (47%) patients were female, 172 (45%) had metastatic disease, and 72 (19%) prior VTE. The primary site of cancer was lung in 48 (13%) patients and breast in 43 (11%). According to the MOS, the rate of VTE recurrence was 4.1% for low, 6.3% intermediate, and 5.5% high risk (p = 0.75); the rate of fatal VTE was 0.8, 1.9, and 2.0% (p = 0.69); the rate of major bleeding was 3.1, 4.1, and 3.6% (p = 0.92); and the rate of death was 6.1, 12.0, and 28.2% (p < 0.001), respectively. None of the MOS items was associated with VTE recurrence: female gender hazard ratio (HR) 1.26 (95% confidence interval [CI], 0.53–2.96), lung cancer HR 1.17 (95% CI, 0.35–3.98), prior VTE HR 0.44 (95% CI, 0.10–1.91), breast cancer HR 0.83 (95% CI, 0.19–3.58), and absence of metastases HR 0.74 (95% CI, 0.31–1.74). In hospitalized patients with cancer-associated VTE, the MOS failed to predict VTE recurrence at 3 months but was associated with early mortality.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/215163
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