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Gliding motility powers invasion and egress in Apicomplexa.

  • Frénal K Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, CMU, 1 Rue Michel-Servet, 1211 Geneva 4, Switzerland.
  • Dubremetz JF Unité Mixte de Recherche 5235 - Dynamique des Interactions Membranaires Normales et Pathologiques, Université Montpellier, Place Eugène Bataillon, 34095 Montpellier cedex 5, France.
  • Lebrun M Unité Mixte de Recherche 5235 - Dynamique des Interactions Membranaires Normales et Pathologiques, Université Montpellier, Place Eugène Bataillon, 34095 Montpellier cedex 5, France.
  • Soldati-Favre D Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, CMU, 1 Rue Michel-Servet, 1211 Geneva 4, Switzerland.
  • 2017-09-05
Published in:
  • Nature reviews. Microbiology. - 2017
Actin Cytoskeleton
Actins
Animals
Apicomplexa
Cell Membrane
Cell Movement
Host-Parasite Interactions
Humans
Models, Biological
Plasmodium falciparum
Protozoan Proteins
Toxoplasma
English Protozoan parasites have developed elaborate motility systems that facilitate infection and dissemination. For example, amoebae use actin-rich membrane extensions called pseudopodia, whereas Kinetoplastida are propelled by microtubule-containing flagella. By contrast, the motile and invasive stages of the Apicomplexa - a phylum that contains the important human pathogens Plasmodium falciparum (which causes malaria) and Toxoplasma gondii (which causes toxoplasmosis) - have a unique machinery called the glideosome, which is composed of an actomyosin system that underlies the plasma membrane. The glideosome promotes substrate-dependent gliding motility, which powers migration across biological barriers, as well as active host cell entry and egress from infected cells. In this Review, we discuss the discovery of the principles that govern gliding motility, the characterization of the molecular machinery involved, and its impact on parasite invasion and egress from infected cells.
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  • English
Open access status
green
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https://sonar.ch/global/documents/216139
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