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Cilazapril in congestive heart failure. A pilot study.
Journal article

Cilazapril in congestive heart failure. A pilot study.

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  • 1991-01-01
Published in:
  • Drugs. - 1991
Adult
Aged
Angiotensin-Converting Enzyme Inhibitors
Cilazapril
Drug Administration Schedule
Exercise Test
Female
Heart Failure
Hemodynamics
Humans
Male
Middle Aged
Pilot Projects
Pyridazines
English The haemodynamic effects of a single dose of cilazapril 2.5 or 5 mg were studied in 33 patients with stable chronic congestive heart failure who were receiving digitalis and diuretics. Subsequently, a double-blind comparison of the haemodynamic and clinical effects of 3 months' treatment with cilazapril 1.25 to 5 mg daily or placebo in 24 evaluable patients revealed that the acute haemodynamic improvement produced by a single dose of cilazapril was maintained in patients receiving repeated administration of the drug, but not in those randomly allocated the placebo. Acute cilazapril significantly decreased mean arterial pressure, systemic vascular resistance, pulmonary capillary wedge pressure, pulmonary artery pressure and right atrial pressure, while cardiac index and stroke volume index increased at rest and during submaximal exercise. After 3 months' treatment 11 of 13 cilazapril recipients improved their New York Heart Association (NYHA) class compared with 2 of 11 patients treated with placebo. This functional improvement was paralleled by a patient-perceived improvement in general well-being.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/216627
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