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Biologics for tendon repair.
Journal article

Biologics for tendon repair.

  • Docheva D Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig Maximilians University, Nussbaumstr. 20, 80336 Munich, Germany. Electronic address: denitsa.docheva@med.uni-muenchen.de.
  • Müller SA Department of Orthopedic Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland.
  • Majewski M Department of Orthopedic Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland.
  • Evans CH Rehabilitation Medicine Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
  • 2014-12-03
Published in:
  • Advanced drug delivery reviews. - 2015
Cell-based therapy
Embryonic stem cells
Gene therapy
Growth Factors
Mesenchymal stem cells
Natural biomaterials
Tendon
Tendon repair
Tendon-derived cells
Biocompatible Materials
Genetic Therapy
Humans
Intercellular Signaling Peptides and Proteins
Regeneration
Stem Cell Transplantation
Tendons
English Tendon injuries are common and present a clinical challenge to orthopedic surgery mainly because these injuries often respond poorly to treatment and require prolonged rehabilitation. Therapeutic options used to repair ruptured tendons have consisted of suture, autografts, allografts, and synthetic prostheses. To date, none of these alternatives has provided a successful long-term solution, and often the restored tendons do not recover their complete strength and functionality. Unfortunately, our understanding of tendon biology lags far behind that of other musculoskeletal tissues, thus impeding the development of new treatment options for tendon conditions. Hence, in this review, after introducing the clinical significance of tendon diseases and the present understanding of tendon biology, we describe and critically assess the current strategies for enhancing tendon repair by biological means. These consist mainly of applying growth factors, stem cells, natural biomaterials and genes, alone or in combination, to the site of tendon damage. A deeper understanding of how tendon tissue and cells operate, combined with practical applications of modern molecular and cellular tools could provide the long awaited breakthrough in designing effective tendon-specific therapeutics and overall improvement of tendon disease management.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/232077
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