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In Europe expression of EBNA2 is associated with poor survival in EBV-positive diffuse large B-cell lymphoma of the elderly.
Journal article

In Europe expression of EBNA2 is associated with poor survival in EBV-positive diffuse large B-cell lymphoma of the elderly.

  • Stuhlmann-Laeisz C a Department of Pathology , Hematopathology Section and Lymph Node Registry, University of Kiel , Germany.
  • Borchert A a Department of Pathology , Hematopathology Section and Lymph Node Registry, University of Kiel , Germany.
  • Quintanilla-Martinez L b Department of Pathology , University of Tübingen , Germany.
  • Hoeller S c Department of Pathology , University of Basel , Switzerland.
  • Tzankov A c Department of Pathology , University of Basel , Switzerland.
  • Oschlies I a Department of Pathology , Hematopathology Section and Lymph Node Registry, University of Kiel , Germany.
  • Kreuz M d IMISE , Leipzig , Germany.
  • Trappe R e Second Department of Medicine , University of Kiel , Germany and 5 DIAKO Bremen , Bremen Germany.
  • Klapper W a Department of Pathology , Hematopathology Section and Lymph Node Registry, University of Kiel , Germany.
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  • 2015-04-23
Published in:
  • Leukemia & lymphoma. - 2016
Age
DLBCL
Ebstein-Barr virus
latency type
Age Factors
Aged
Aged, 80 and over
Epstein-Barr Virus Infections
Epstein-Barr Virus Nuclear Antigens
Europe
Female
Gene Expression
Herpesvirus 4, Human
Humans
Incidence
Kaplan-Meier Estimate
Lymph Nodes
Lymphoma, Large B-Cell, Diffuse
Male
Middle Aged
Prognosis
Virus Latency
English Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) of the elderly occurs by definition in patients above the age of 50 years without any known underlying immunodeficiency. We investigated the incidence and clinical relevance of this subtype in Europe with special attention to the EBV-latency type. Among the 598 DLBCL, 15 EBV-positive lymphomas fulfilling the criteria of EBV-positive DLBCL of the elderly were identified (2.5%). Patients with EBV-positive DLBCL expressing EBNA2 showed a significantly poorer overall survival than patients with EBNA2-negative EBV-positive DLBCL (p = 0.0156). The incidence of EBV-positive DLBCL of the elderly in Europe is much lower than in Asian countries (2.5% of all cases of DLBCL). Interestingly, the likelihood of EBV positivity did not increase with age in patient above 50 years. Among EBV-positive DLBCL of the elderly a subgroup with EBV-latency type III expressing EBNA2 can be identified, which shows a poor outcome.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/232170
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