Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients.
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Michels S
Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Network Genomic Medicine, Cologne, Germany.
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Scheel AH
Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
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Scheffler M
Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Network Genomic Medicine, Cologne, Germany.
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Schultheis AM
Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
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Gautschi O
Department for Medical Oncology, Lucerne Cantonal Hospital, Lucerne, Switzerland.
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Aebersold F
Institute of Pathology, Lucerne Cantonal Hospital, Lucerne, Switzerland.
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Diebold J
Institute of Pathology, Lucerne Cantonal Hospital, Lucerne, Switzerland.
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Pall G
Department for Internal Medicine, Haematology and Oncology, University Hospital Innsbruck, Innsbruck, Austria.
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Rothschild S
Department for Oncology, University Hospital Basel, Basel, Switzerland.
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Bubendorf L
Department for Cytopathology, University Hospital Basel, Basel, Switzerland.
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Hartmann W
Gerhard-Domagk-Institute of Pathology, University Hospital of Münster, Münster, Germany.
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Heukamp L
Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
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Schildhaus HU
Institute of Pathology, University Hospital of Göttigen, Göttingen, Germany.
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Fassunke J
Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
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Ihle MA
Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
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Künstlinger H
Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
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Heydt C
Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
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Fischer R
Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Network Genomic Medicine, Cologne, Germany.
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Nogovà L
Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Network Genomic Medicine, Cologne, Germany.
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Mattonet C
Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Network Genomic Medicine, Cologne, Germany.
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Hein R
Institute of Medical Statistics, Informatics and Epidemiology, University Hospital of Cologne, Cologne, Germany.
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Adams A
Institute of Medical Statistics, Informatics and Epidemiology, University Hospital of Cologne, Cologne, Germany.
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Gerigk U
Thoracic Centre, Malteser Hospital Bonn/Rhein-Sieg, Bonn, Germany.
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Schulte W
Departent for Pulmonology Cardiology and Allergology, Johanniter Hospital, Bonn, Germany.
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Lüders H
Evangelic Lung Clinic Berlin, Department of Pneumology, Berlin, Germany.
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Grohé C
Evangelic Lung Clinic Berlin, Department of Pneumology, Berlin, Germany.
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Graeven U
Department for Hematology, Oncology and Gastroenterology, Maria Hilf Hospital Mönchengladbach, Mönchengladbach, Germany.
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Müller-Naendrup C
Private Practice for Oncology, Medical Centre II (Martinus Höfe), Olpe, Germany.
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Draube A
Department for Internal Medicine, St. Vinzenz Hospital Cologne, Cologne, Germany.
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Kambartel KO
Department for Pulmonology and Allergology, Bethanien Hospital Moers, Moers, Germany.
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Krüger S
Department for Pulmonology/Allergology/Sleep Medicine and Respiratory Care, Florence-Nightingale-Hospital, Düsseldorf, Germany.
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Schulze-Olden S
Department for Pulmonology/Allergology/Sleep Medicine and Respiratory Care, Florence-Nightingale-Hospital, Düsseldorf, Germany.
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Serke M
Department for Pulmonology and Thoracic Oncology, Lung Clinic Hemer, Hemer, Germany.
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Engel-Riedel W
Lung Clinic Merheim, Hospitals of Cologne, Cologne, Germany.
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Kaminsky B
Clinic for Pulmonology and Allergology, Bethanien Hospital, Solingen, Germany.
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Randerath W
Clinic for Pulmonology and Allergology, Bethanien Hospital, Solingen, Germany.
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Merkelbach-Bruse S
Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
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Büttner R
Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
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Wolf J
Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Network Genomic Medicine, Cologne, Germany. Electronic address: juergen.wolf@uk-koeln.de.
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Published in:
- Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. - 2016
English
INTRODUCTION
Rearrangements of RET are rare oncogenic events in patients with non-small cell lung cancer (NSCLC). While the characterization of Asian patients suggests a predominance of nonsmokers of young age in this genetically defined lung cancer subgroup, little is known about the characteristics of non-Asian patients. We present the results of an analysis of a European cohort of patients with RET rearranged NSCLC.
METHODS
Nine hundred ninety-seven patients with KRAS/EGFR/ALK wildtype lung adenocarcinomas were analyzed using fluorescence in situ hybridization for RET fusions. Tumor specimens were molecularly profiled and clinicopathological characteristics of the patients were collected.
RESULTS
Rearrangements of RET were identified in 22 patients, with a prevalence of 2.2% in the KRAS/EGFR/ALK wildtype subgroup. Co-occurring genetic aberrations were detected in 10 patients, and the majority had mutations in TP53. The median age at diagnosis was 62 years (range, 39-80 years; mean ± SD, 61 ± 11.7 years) with a higher proportion of men (59% versus 41%). There was only a slight predominance of nonsmokers (54.5%) compared to current or former smokers (45.5%).
CONCLUSIONS
Patients with RET rearranged adenocarcinomas represent a rare and heterogeneous NSCLC subgroup. In some contrast to published data, we see a high prevalence of current and former smokers in our white RET cohort. The significance of co-occurring aberrations, so far, is unclear.
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bronze
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Persistent URL
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https://sonar.ch/global/documents/232375
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